PMID- 18510607
OWN - NLM
STAT- MEDLINE
DCOM- 20080729
LR  - 20080612
IS  - 1572-0241 (Electronic)
IS  - 0002-9270 (Linking)
VI  - 103
IP  - 6
DP  - 2008 Jun
TI  - The effect of hypnosis on systemic and rectal mucosal measures of inflammation in 
      ulcerative colitis.
PG  - 1460-9
LID - 10.1111/j.1572-0241.2008.01845.x [doi]
AB  - OBJECTIVES: Hypnotherapy is effective in several diseases with a psychosomatic 
      component. Our aim was to study the effects of one session of hypnosis on the 
      systemic and rectal mucosal inflammatory responses in patients with active 
      ulcerative colitis (UC). METHODS: In total, 17 patients with active UC underwent 
      a 50-min session of gut-focused hypnotherapy. Before and after each procedure, 
      the systemic inflammatory response was assessed by serum interleukin (IL)-6 and 
      IL-13 concentrations, tumor necrosis factor-alpha (TNF-alpha) and IL-6 production 
      by lipopolysaccharide (LPS)-stimulated whole blood, leukocyte count, natural 
      killer (NK) cell number, platelet activation, and platelet-leukocyte aggregate 
      formation. Rectal inflammation was assessed by mucosal release of substance P 
      (SP), histamine, IL-13 and TNF-alpha, reactive oxygen metabolite production, and 
      mucosal blood flow. Eight patients with active UC underwent a control procedure. 
      RESULTS: Hypnosis decreased pulse by a median 7 beats per minute (bpm) (P= 
      0.0008); it also reduced the median serum IL-6 concentration by 53% (P= 0.001), 
      but had no effect on the other systemic variables assessed. Hypnosis reduced 
      rectal mucosal release of SP by a median 81% (P= 0.001), histamine by 35% (P= 
      0.002) and IL-13 by 53% (P= 0.003), and also, blood flow by 18% (P= 0.0004). The 
      control protocol had no effect on any of the variables assessed. CONCLUSIONS: 
      Hypnosis reduced several components of the systemic and mucosal inflammatory 
      response in active ulcerative colitis toward levels found previously in the 
      inactive disease. Some of these effects may contribute to the anecdotally 
      reported benefits of hypnotherapy and provide a rationale for controlled trials 
      of hypnotherapy in UC.
FAU - Mawdsley, Joel E
AU  - Mawdsley JE
AD  - Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and 
      the London, Queen Mary School of Medicine and Dentistry, London, UK.
FAU - Jenkins, David G
AU  - Jenkins DG
FAU - Macey, Marion G
AU  - Macey MG
FAU - Langmead, Louise
AU  - Langmead L
FAU - Rampton, David S
AU  - Rampton DS
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20080528
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adult
MH  - Colitis, Ulcerative/metabolism/pathology/*therapy
MH  - Cytokines/*metabolism
MH  - Female
MH  - Humans
MH  - *Hypnosis
MH  - Inflammation Mediators/*metabolism
MH  - Intestinal Mucosa/blood supply/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Rectum/blood supply/metabolism/pathology
MH  - Regional Blood Flow/physiology
MH  - Sigmoidoscopy
MH  - Treatment Outcome
EDAT- 2008/05/31 09:00
MHDA- 2008/07/30 09:00
CRDT- 2008/05/31 09:00
PHST- 2008/05/31 09:00 [pubmed]
PHST- 2008/07/30 09:00 [medline]
PHST- 2008/05/31 09:00 [entrez]
AID - AJG1845 [pii]
AID - 10.1111/j.1572-0241.2008.01845.x [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2008 Jun;103(6):1460-9. doi: 
      10.1111/j.1572-0241.2008.01845.x. Epub 2008 May 28.