PMID- 18511076
OWN - NLM
STAT- MEDLINE
DCOM- 20090319
LR  - 20220408
IS  - 0022-3956 (Print)
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 43
IP  - 3
DP  - 2009 Jan
TI  - Changes in BDNF serum levels in patients with major depression disorder (MDD) 
      after 6 months treatment with sertraline, escitalopram, or venlafaxine.
PG  - 247-54
LID - 10.1016/j.jpsychires.2008.03.014 [doi]
AB  - Recent studies have implicated brain-derived neurotrophic factor (BDNF) in the 
      pathophysiology of depression and the activity of antidepressant drugs. Serum 
      BDNF levels are lower in depressed patients, and increase in response to 
      antidepressant medication. However, how BDNF responds to different classes of 
      antidepressant drugs is unknown. We assessed serum BDNF levels in 21 patients 
      with major depressive episode treated with sertraline, escitalopram, or 
      venlafaxine and 20 healthy controls. Serum samples were collected between 10 a.m. 
      and 12 p.m. at baseline, 5 weeks, and 6 months of treatment. BDNF levels were 
      measured via immunoassay. The severity of symptoms and response to treatment were 
      assessed by the Hamilton rating scales for depression (HRSD). Baseline serum BDNF 
      levels were significantly lower in depressed patients compared to controls. 
      Sertraline increased BDNF levels after 5 weeks and 6 months of treatment. 
      Venlafaxine increased BDNF levels only after 6 months. Escitalopram did not 
      affect BDNF levels at either time point. A significant negative association was 
      found between percentage increase in BDNF levels and percentage decreased in HRSD 
      scores after 6 months of treatment. In conclusion, these results suggest that 
      different antidepressant drugs have variable effects on serum BDNF levels. This 
      is true even though the three different drugs were equally effective in relieving 
      symptoms of depression and anxiety.
FAU - Matrisciano, Francesco
AU  - Matrisciano F
AD  - Department of Psychiatry and Psychological Medicine, University of Rome "La 
      Sapienza" "Sant'Andrea" Hospital, Via di Grottarossa, 1035/1039, 00189 Rome, 
      Italy.
FAU - Bonaccorso, Stefania
AU  - Bonaccorso S
FAU - Ricciardi, Angelo
AU  - Ricciardi A
FAU - Scaccianoce, Sergio
AU  - Scaccianoce S
FAU - Panaccione, Isabella
AU  - Panaccione I
FAU - Wang, Lily
AU  - Wang L
FAU - Ruberto, Amedo
AU  - Ruberto A
FAU - Tatarelli, Roberto
AU  - Tatarelli R
FAU - Nicoletti, Ferdinando
AU  - Nicoletti F
FAU - Girardi, Paolo
AU  - Girardi P
FAU - Shelton, Richard C
AU  - Shelton RC
LA  - eng
GR  - R01 MH073630/MH/NIMH NIH HHS/United States
GR  - MH073630/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080603
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclohexanols)
RN  - 0DHU5B8D6V (Citalopram)
RN  - 7D7RX5A8MO (Venlafaxine Hydrochloride)
RN  - QUC7NX6WMB (Sertraline)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Citalopram/*therapeutic use
MH  - Cyclohexanols/*therapeutic use
MH  - Depressive Disorder, Major/blood/diagnosis/*drug therapy
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Sertraline/*therapeutic use
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Venlafaxine Hydrochloride
PMC - PMC3744240
MID - NIHMS91602
EDAT- 2008/05/31 09:00
MHDA- 2009/03/20 09:00
PMCR- 2013/08/15
CRDT- 2008/05/31 09:00
PHST- 2008/01/17 00:00 [received]
PHST- 2008/03/17 00:00 [revised]
PHST- 2008/03/25 00:00 [accepted]
PHST- 2008/05/31 09:00 [pubmed]
PHST- 2009/03/20 09:00 [medline]
PHST- 2008/05/31 09:00 [entrez]
PHST- 2013/08/15 00:00 [pmc-release]
AID - S0022-3956(08)00073-3 [pii]
AID - 10.1016/j.jpsychires.2008.03.014 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2009 Jan;43(3):247-54. doi: 10.1016/j.jpsychires.2008.03.014. 
      Epub 2008 Jun 3.