PMID- 18511431
OWN - NLM
STAT- MEDLINE
DCOM- 20081023
LR  - 20100917
IS  - 1096-0929 (Electronic)
IS  - 1096-0929 (Linking)
VI  - 105
IP  - 1
DP  - 2008 Sep
TI  - Effects of perfluorobutyrate exposure during pregnancy in the mouse.
PG  - 173-81
LID - 10.1093/toxsci/kfn099 [doi]
AB  - Perfluorobutyrate (PFBA) is a perfluoroalkyl acid (PFAA) found in the 
      environment. Previous studies have indicated developmental toxicity of PFAAs 
      (perfluorooctane sulfonate [PFOS] and perfluorooctanoate [PFOA]); the current 
      study examines that of PFBA. PFBA/NH4(+) was given to timed-pregnant CD-1 mice by 
      oral gavage daily from gestational day (GD) 1 to 17 at 35, 175, or 350 mg/kg 
      (chosen to approximate the developmentally toxic doses of PFOA); controls 
      received water. At GD 18, serum levels of PFBA were 3.8, 4.4, and 2.5 microg/ml, 
      respectively, in the three treated groups. PFBA did not significantly affect 
      maternal weight gain, number of implantations, fetal viability, fetus weight, or 
      incidence of fetal malformations. Incidence of full-litter loss was significantly 
      greater in the 350 mg/kg group, and maternal liver weights were significantly 
      increased in the 175 and 350 mg/kg groups. In contrast to PFOA and PFOS, PFBA 
      exposure during pregnancy did not adversely affect neonatal survival or postnatal 
      growth. Liver enlargement was detected in the PFBA-exposed pups on postnatal day 
      (PD) 1, but not by PD 10. Expression of selected hepatic genes in PFBA-exposed 
      pups at PD 1 did not reveal any significant changes from controls. A significant 
      delay in eye-opening in offspring was detected in all three PFBA groups, and 
      slight delays in the onset of puberty were noted in the 175 and 350 mg/kg groups. 
      These data suggest that exposure to PFBA during pregnancy in the mouse did not 
      produce developmental toxicity comparable to that observed with PFOA, in part, 
      due to rapid elimination of the chemical.
FAU - Das, Kaberi P
AU  - Das KP
AD  - Reproductive Toxicology Division, National Health and Environmental Effects 
      Research Laboratory, Office of Research and Development, U.S. Environmental 
      Protection Agency, Research Triangle Park, North Carolina 27711, USA.
FAU - Grey, Brian E
AU  - Grey BE
FAU - Zehr, Robert D
AU  - Zehr RD
FAU - Wood, Carmen R
AU  - Wood CR
FAU - Butenhoff, John L
AU  - Butenhoff JL
FAU - Chang, Shu-Ching
AU  - Chang SC
FAU - Ehresman, David J
AU  - Ehresman DJ
FAU - Tan, Yu-Mei
AU  - Tan YM
FAU - Lau, Christopher
AU  - Lau C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080528
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Fluorocarbons)
RN  - 375-22-4 (perfluorobutyric acid)
RN  - 76-21-1 (hexadecafluoro-nonanoic acid)
SB  - IM
MH  - Abnormalities, Drug-Induced
MH  - Animals
MH  - Body Weight/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Fetus/*drug effects
MH  - Fluorocarbons/blood/*toxicity
MH  - Gene Expression/drug effects
MH  - Growth/drug effects
MH  - Liver/drug effects/metabolism
MH  - Mice
MH  - Organ Size/drug effects
MH  - Pregnancy
EDAT- 2008/05/31 09:00
MHDA- 2008/10/24 09:00
CRDT- 2008/05/31 09:00
PHST- 2008/05/31 09:00 [pubmed]
PHST- 2008/10/24 09:00 [medline]
PHST- 2008/05/31 09:00 [entrez]
AID - kfn099 [pii]
AID - 10.1093/toxsci/kfn099 [doi]
PST - ppublish
SO  - Toxicol Sci. 2008 Sep;105(1):173-81. doi: 10.1093/toxsci/kfn099. Epub 2008 May 
      28.