PMID- 18514407
OWN - NLM
STAT- MEDLINE
DCOM- 20081014
LR  - 20080610
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 439
IP  - 2
DP  - 2008 Jul 11
TI  - Increased serum levels of brain-derived neurotrophic factor in chronic 
      institutionalized patients with schizophrenia.
PG  - 157-9
LID - 10.1016/j.neulet.2008.05.022 [doi]
AB  - There is a growing body of evidence implicating the neurotrophin brain-derived 
      neurotrophic factor (BDNF) in the pathogenesis of schizophrenia. As circulating 
      BDNF levels may reflect the BDNF levels in the brain, we assessed serum BDNF in 
      40 institutionalized schizophrenic patients and 20 healthy controls. Serum BNDF 
      levels were significantly increased in schizophrenic patients when compared to 
      control subjects (p<0.001). Interestingly, serum BDNF correlated positively with 
      the clinical scores at the negative subscale of the positive and negative 
      syndrome scale (PANSS) (r=0.41; p<0.01). Our results confirm the emergent 
      literature on the involvement of BDNF in schizophrenia.
FAU - Reis, Helton Jose
AU  - Reis HJ
AD  - Group of Neuroimmunology, Laboratory of Immunopharmacology, Department of 
      Biochemistry and Immunology, Institute of Biological Sciences, Federal University 
      of Minas Gerais, Belo Horizonte, Brazil.
FAU - Nicolato, Rodrigo
AU  - Nicolato R
FAU - Barbosa, Izabela Guimaraes
AU  - Barbosa IG
FAU - Teixeira do Prado, Paulo Henrique
AU  - Teixeira do Prado PH
FAU - Romano-Silva, Marco Aurelio
AU  - Romano-Silva MA
FAU - Teixeira, Antonio Lucio
AU  - Teixeira AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080513
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - *Hospitals, Psychiatric
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Regression Analysis
MH  - Schizophrenia/*blood
EDAT- 2008/06/03 09:00
MHDA- 2008/10/15 09:00
CRDT- 2008/06/03 09:00
PHST- 2008/03/25 00:00 [received]
PHST- 2008/04/28 00:00 [revised]
PHST- 2008/05/08 00:00 [accepted]
PHST- 2008/06/03 09:00 [pubmed]
PHST- 2008/10/15 09:00 [medline]
PHST- 2008/06/03 09:00 [entrez]
AID - S0304-3940(08)00652-6 [pii]
AID - 10.1016/j.neulet.2008.05.022 [doi]
PST - ppublish
SO  - Neurosci Lett. 2008 Jul 11;439(2):157-9. doi: 10.1016/j.neulet.2008.05.022. Epub 
      2008 May 13.