PMID- 1851451
OWN - NLM
STAT- MEDLINE
DCOM- 19910619
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 542
IP  - 2
DP  - 1991 Mar 1
TI  - Median preoptic nucleus projections to vasopressin-containing neurones of the 
      supraoptic nucleus in sheep. A light and electron microscopic study.
PG  - 193-200
AB  - It has been postulated that osmoreceptors are situated in either or both of two 
      components of the lamina terminalis, the subfornical organ (sfo) and organum 
      vasculosum laminae terminalis (ovlt) and that information from these sites may be 
      relayed to the hypothalamus directly or via a synapse in the median preoptic 
      nucleus (mnpo). We have investigated the nature of projections from the mnpo to 
      vasopressin (AVP)-containing neurones in the hypothalamus. Microinjections of 
      horseradish peroxidase-wheat germ agglutinin (HRP-WGA) have been made into the 
      mnpo and supraoptic nucleus (son) of the sheep. These injections indicated that 
      in the sheep, as in the rat, the mnpo shares a reciprocal innervation with the 
      sfo and ovlt. Furthermore, the most extensive efferent outflow of the mnpo is to 
      the son, with lesser projections directed to the pvn and other hypothalamic 
      sites. When examined at the electron microscopic level, fibres projecting from 
      the mnpo to the son were found to form synapses with immunocytochemically 
      identified AVP neurones. It is suggested that this pathway is one of the major 
      routes by which information from putative osmoreceptors in the lamina terminalis 
      is conveyed to AVP neurones in the hypothalamus.
FAU - Oldfield, B J
AU  - Oldfield BJ
AD  - Howard Florey Institute of Experimental Physiology and Medicine, University of 
      Melbourne, Parkville, Australia.
FAU - Miselis, R R
AU  - Miselis RR
FAU - McKinley, M J
AU  - McKinley MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Wheat Germ Agglutinins)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - EC 1.11.1.- (Horseradish Peroxidase)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/*metabolism
MH  - Brain Mapping
MH  - Horseradish Peroxidase
MH  - Microscopy, Immunoelectron
MH  - Neurons/*metabolism
MH  - Preoptic Area/*physiology
MH  - Sheep
MH  - Supraoptic Nucleus/cytology/*metabolism/ultrastructure
MH  - *Synaptic Transmission
MH  - Wheat Germ Agglutinins
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
AID - 0006-8993(91)91566-J [pii]
AID - 10.1016/0006-8993(91)91566-j [doi]
PST - ppublish
SO  - Brain Res. 1991 Mar 1;542(2):193-200. doi: 10.1016/0006-8993(91)91566-j.