PMID- 18514768
OWN - NLM
STAT- MEDLINE
DCOM- 20081202
LR  - 20131121
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 72
IP  - 5
DP  - 2008 Nov
TI  - The effects of artery-ligating and artery-preserving varicocelectomy on the 
      ipsilateral testes in rats.
PG  - 1179-84
LID - 10.1016/j.urology.2008.03.035 [doi]
AB  - OBJECTIVES: To investigate the effects of artery-ligating varicocelectomy (ALV) 
      and artery-preserving varicocelectomy (APV) on the ipsilateral testes in 
      experimental varicocele (EV) rats. METHODS: Fifty adolescent male Sprague-Dawley 
      rats (6 weeks old, weighing 170 +/- 10 g) were randomly divided into 4 groups: EV 
      without treatment group (EV group), EV with ALV group (EV+ALV group), EV with APV 
      group (EV+APV group), and a control group. EV was induced by partial ligation of 
      the left renal vein to an external diameter of 50% of its original at the 
      position of medialis to both the adrenal and internal spermatic veins. ALV was 
      performed by total ligation of the dilated left internal spermatic vein, along 
      with the internal spermatic artery. APV was performed by ligation of the dilated 
      left internal spermatic vein only. Johnsen's score, ultrastructure of 
      seminiferous tubules, and intratesticular testosterone concentration (ITC) of the 
      left testes were measured. RESULTS: ITC and Johnsen's score in the control group 
      were significantly higher than those in the EV group (P < .05) and markedly 
      higher than those in the EV+ALV group (P < .01), and no statistical difference 
      compared with those in the EV+APV group (P > .05). Ultrastructural abnormalities 
      of seminiferous tubules were observed in the EV group, especially in the EV+ALV 
      group. CONCLUSIONS: APV was able to repair the varicocele-induced lesions of 
      ipsilateral testes; whereas, the ALV caused further lesions.
FAU - Zheng, Yi-Qun
AU  - Zheng YQ
AD  - Department of Urology, Renmin Hospital, Wuhan University, Wuhan, China.
FAU - Zhang, Xiao-Bin
AU  - Zhang XB
FAU - Zhou, Jiang-Qiao
AU  - Zhou JQ
FAU - Cheng, Fan
AU  - Cheng F
FAU - Rao, Ting
AU  - Rao T
FAU - Yao, Yi
AU  - Yao Y
LA  - eng
PT  - Journal Article
DEP - 20080602
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Animals
MH  - Hemostasis, Surgical/*methods
MH  - Ligation
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spermatic Cord/*blood supply/pathology/*surgery
MH  - Spermatogenesis
MH  - Suture Techniques
MH  - Testis/*blood supply/metabolism/*pathology
MH  - Testosterone/metabolism
MH  - Varicocele/metabolism/pathology/*surgery
EDAT- 2008/06/03 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/06/03 09:00
PHST- 2007/08/24 00:00 [received]
PHST- 2008/03/20 00:00 [revised]
PHST- 2008/03/21 00:00 [accepted]
PHST- 2008/06/03 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/06/03 09:00 [entrez]
AID - S0090-4295(08)00374-9 [pii]
AID - 10.1016/j.urology.2008.03.035 [doi]
PST - ppublish
SO  - Urology. 2008 Nov;72(5):1179-84. doi: 10.1016/j.urology.2008.03.035. Epub 2008 
      Jun 2.