PMID- 18514935
OWN - NLM
STAT- MEDLINE
DCOM- 20080922
LR  - 20151119
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 14
IP  - 5
DP  - 2008 Jun
TI  - Plasma brain natriuretic peptide predicts short-term clinical outcome in heart 
      failure patients with restrictive filling pattern.
PG  - 420-5
LID - 10.1016/j.cardfail.2008.01.013 [doi]
AB  - OBJECTIVE: Plasma brain natriuretic peptide (BNP) is an important parameter of 
      severity in congestive heart failure (CHF). We analyzed if BNP might stratify 
      6-month clinical outcome in outpatients with CHF with restrictive mitral filling 
      pattern. METHODS: All subjects with New York Heart Association (NYHA) class II to 
      IV and restrictive filling pattern were enrolled at hospital discharge after an 
      acute decompensation. NYHA class, BNP, and echocardiogram for the evaluation of 
      left ventricular ejection fraction (LVEF) and diastolic function were analyzed. 
      Death and hospital readmission for CHF were the clinical events observed. 
      RESULTS: A total of 250 patients (66% were male, mean age 73 years) were 
      enrolled. The mean NYHA class was 2.5 +/- 0.6, LVEF was 38% +/- 15%, and mean 
      deceleration time was 120 +/- 16 ms. The mean BNP was 643 +/- 566 pg/mL. During 
      the 6-month follow-up, 35 patients (14%) died and 106 patients (42.4%) were 
      readmitted for CHF (event group); in 109 patients (43.6%) no events were observed 
      (no-event group). Higher NYHA class (2.7 +/- 0.6 vs 2.4 +/- 0.6, P = .001) and 
      reduced LVEF (34% +/- 13% vs 42% +/- 17%, P = .01) but similar deceleration time 
      (119 +/- 16 ms vs 122 +/- 17 ms, P = not significant) were observed in the event 
      group. A higher level of mean BNP (833 +/- 604 pg/mL vs 397 +/- 396 pg/mL, P = 
      .01) was recorded in the event group. The multivariate Cox analysis confirmed 
      that LVEF (P = .04), NYHA class (P = .02), and plasma BNP (P = .0001) were 
      associated with adverse short-term clinical outcome. CONCLUSION: Patients with 
      CHF with a restrictive diastolic pattern had poor short-term clinical outcome. 
      NYHA class and LVEF at discharge might predict cardiovascular events, but plasma 
      BNP proved to be the strongest predictor.
FAU - Feola, Mauro
AU  - Feola M
AD  - Department of Cardiovascular Diseases Ospedale Santa Croce-Carle Cuneo, Cuneo, 
      Italy.
FAU - Aspromonte, Nadia
AU  - Aspromonte N
FAU - Milani, Loredano
AU  - Milani L
FAU - Bobbio, Marco
AU  - Bobbio M
FAU - Bardellotto, Stefania
AU  - Bardellotto S
FAU - Barro, Sabrina
AU  - Barro S
FAU - Giovinazzo, Prospero
AU  - Giovinazzo P
FAU - Noventa, Federica
AU  - Noventa F
FAU - Valle, Roberto
AU  - Valle R
LA  - eng
PT  - Journal Article
DEP - 20080527
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Diastole
MH  - Echocardiography, Doppler
MH  - Female
MH  - Heart Failure/*blood/drug therapy/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Prognosis
MH  - Prospective Studies
MH  - *Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2008/06/03 09:00
MHDA- 2008/09/23 09:00
CRDT- 2008/06/03 09:00
PHST- 2007/09/10 00:00 [received]
PHST- 2008/01/23 00:00 [revised]
PHST- 2008/01/23 00:00 [accepted]
PHST- 2008/06/03 09:00 [pubmed]
PHST- 2008/09/23 09:00 [medline]
PHST- 2008/06/03 09:00 [entrez]
AID - S1071-9164(08)00041-9 [pii]
AID - 10.1016/j.cardfail.2008.01.013 [doi]
PST - ppublish
SO  - J Card Fail. 2008 Jun;14(5):420-5. doi: 10.1016/j.cardfail.2008.01.013. Epub 2008 
      May 27.