PMID- 18516002
OWN - NLM
STAT- MEDLINE
DCOM- 20081231
LR  - 20181201
IS  - 1598-9992 (Print)
IS  - 1598-9992 (Linking)
VI  - 51
IP  - 4
DP  - 2008 Apr
TI  - [The effect of proton pump inhibitor on healing of post-esophageal variceal 
      ligation ulcers].
PG  - 232-40
AB  - BACKGROUND/AIMS: Esophageal variceal ligation (EVL) is the most preferable method 
      for controlling variceal bleeding. However, EVL is associated with complications 
      such as hemorrhage, chest pain, dysphagia, and odynophagia due to post-EVL ulcers 
      in the esophageal mucosa. The aim of this study was to assess the effect of 
      proton pump inhibitor (PPI), pantoprazole on the healing of post-EVL ulcers. 
      METHODS: Forty seven patients were randomly allocated into PPI group and control 
      group. Patients in PPI group received 40 mg of pantoprazole intravenously for 3 
      days after EVL, then 40 mg of oral pantoprazole for 11 days consecutively. 
      Control patients received intravenous and oral placebo. Endoscopic examinations 
      were performed twice at 7+/-2 days and 14+/-2 days after EVL respectively. 
      Clinical outcomes include the size of ulcers, symptoms reported by patients; 
      chest pain, dysphagia, and odynophagia. RESULTS: Forty seven patients completed 
      the 7 days protocol (PPI/control; 25/22), and twenty six patients completed the 
      14 days protocol (PPI/control; 16/10). Post-EVL ulcers in PPI group were 
      significantly smaller than those in control group (7 days; 98.7 mm2/119.4 m2, 14 
      days; 32.3 m2/43.8 m2, p<0.01). No difference was observed between two the groups 
      with respect to summations of symptom scores (p> 0.05). Nineteen patients 
      (PPI/control; 9/10) did not complete the 14 days protocol due to patients' 
      refusal and adverse outcomes, such as hepatic failure and sepsis with bleeding 
      from post-EVL ulcer occurred in two patients of control group. CONCLUSIONS: PPI 
      treatment following EVL may be effective in healing post-EVL ulcer.
FAU - Boo, Gwi Beom
AU  - Boo GB
AD  - Department of Internal Medicine, Chosun University College of Medicine, Gwangju, 
      Korea. boogbim@yahoo.co.kr
FAU - Oh, Jong Chan
AU  - Oh JC
FAU - Lee, Beom Ju
AU  - Lee BJ
FAU - Lee, Dong Min
AU  - Lee DM
FAU - Kim, Young Dae
AU  - Kim YD
FAU - Park, Chan Guk
AU  - Park CG
FAU - Kim, Man Woo
AU  - Kim MW
LA  - kor
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Korea (South)
TA  - Korean J Gastroenterol
JT  - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
JID - 101189416
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - D8TST4O562 (Pantoprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/administration & dosage/*therapeutic use
MH  - Anti-Ulcer Agents/administration & dosage/*therapeutic use
MH  - Esophageal and Gastric Varices/complications/*surgery
MH  - Esophagoscopy
MH  - Female
MH  - Gastrointestinal Hemorrhage/prevention & control
MH  - Humans
MH  - Ligation
MH  - Male
MH  - Middle Aged
MH  - Pantoprazole
MH  - Proton Pump Inhibitors/administration & dosage/*therapeutic use
MH  - Regression Analysis
MH  - Sickness Impact Profile
MH  - Ulcer/*drug therapy/etiology
EDAT- 2008/06/03 09:00
MHDA- 2009/01/01 09:00
CRDT- 2008/06/03 09:00
PHST- 2008/06/03 09:00 [pubmed]
PHST- 2009/01/01 09:00 [medline]
PHST- 2008/06/03 09:00 [entrez]
AID - 200804254 [pii]
PST - ppublish
SO  - Korean J Gastroenterol. 2008 Apr;51(4):232-40.