PMID- 18516251
OWN - NLM
STAT- MEDLINE
DCOM- 20080804
LR  - 20240312
IS  - 1094-4087 (Electronic)
IS  - 1094-4087 (Linking)
VI  - 16
IP  - 9
DP  - 2008 Apr 28
TI  - Measuring retinal contributions to the optical Stiles-Crawford effect with 
      optical coherence tomography.
PG  - 6486-501
LID - 10.1364/OE.16.006486 [doi]
AB  - The directional component of the retinal reflection, i.e., the optical 
      Stiles-Crawford effect (SCE), is well established to result from the waveguiding 
      property of photoreceptors. Considerable uncertainty, however, remains as to 
      which retinal reflections are waveguided and thus contribute. To this end we have 
      developed a retina camera based on spectral-domain optical coherence tomography 
      (SD-OCT) that axially resolves (approximately 5 microm) these reflections and 
      permits a direct investigation of the SCE origin at near infrared wavelengths. 
      Reflections from the photoreceptor inner/outer segments junction (IS/OS) and near 
      the posterior tip of the outer segments (PTOS) were found highly sensitive to 
      beam entry position in the pupil with a considerable decrease in brightness 
      occurring with an increase in aperture eccentricity. Reflections from the retinal 
      pigment epithelium (RPE) were largely insensitive. The average directionality 
      (rho(oct) value) at 2 degree eccentricity across the four subjects for the IS/OS, 
      PTOS, and RPE were 0.120, 0.270, and 0.016 mm(-2), respectively. The 
      directionality for the IS/OS approached typical psychophysical SCE measurements, 
      while that for the PTOS approached conventional optical SCE measurements. Precise 
      measurement of the optical SCE was found to require significant A-scan averaging.
FAU - Gao, Weihua
AU  - Gao W
AD  - School of Optometry, Indiana University, Bloomington, Indiana 47405, USA.
FAU - Cense, Barry
AU  - Cense B
FAU - Zhang, Yan
AU  - Zhang Y
FAU - Jonnal, Ravi S
AU  - Jonnal RS
FAU - Miller, Donald T
AU  - Miller DT
LA  - eng
GR  - R01 EY018339/EY/NEI NIH HHS/United States
GR  - 1R01 EY018339/EY/NEI NIH HHS/United States
GR  - R01 EY014743-06/EY/NEI NIH HHS/United States
GR  - 5R01 EY014743/EY/NEI NIH HHS/United States
GR  - R01 EY018339-01/EY/NEI NIH HHS/United States
GR  - R01 EY014743/EY/NEI NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Opt Express
JT  - Optics express
JID - 101137103
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - *Optics and Photonics
MH  - Pupil/physiology
MH  - Retina/*physiology
MH  - *Tomography, Optical Coherence
PMC - PMC2405946
MID - NIHMS48783
EDAT- 2008/06/03 09:00
MHDA- 2008/08/05 09:00
PMCR- 2008/05/30
CRDT- 2008/06/03 09:00
PHST- 2008/06/03 09:00 [pubmed]
PHST- 2008/08/05 09:00 [medline]
PHST- 2008/06/03 09:00 [entrez]
PHST- 2008/05/30 00:00 [pmc-release]
AID - 10.1364/OE.16.006486 [doi]
PST - ppublish
SO  - Opt Express. 2008 Apr 28;16(9):6486-501. doi: 10.1364/OE.16.006486.