PMID- 18516267 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20111110 LR - 20211020 IS - 1176-6336 (Print) IS - 1178-203X (Electronic) IS - 1176-6336 (Linking) VI - 3 IP - 6 DP - 2007 Dec TI - Association between homocysteinemia and metabolic syndrome in patients with cardiovascular disease. PG - 999-1001 AB - BACKGROUND: This is an observational study undertaken in aim to evaluate the association between metabolic syndrome (MS) and high homocysteinemia (HHcy) in relation with cardiovascular disease (CVD). METHODS: The study involved 126 subjects with angiographically documented CVD and 65 healthy subjects. MS has been diagnosed according to the ATP III criteria and plasma homocysteine concentration has been evaluated. RESULTS: In patients with CVD the prevalence of MS and HHcy is 17.4% and 25.4% respectively; MS coexists with HHcy in 67.2% of patients; analogous results can be observed among men and women. HHcy and MS are associated with CVD (OR 2.53, 95% CI 1.95-12.43 and OR 5.74, 95% CI 2.67-12.34 respectively) but the presence of the two conditions gives rise to a stronger increase in CVD risk (OR 13.11, 95% CI 5.27-32.06). CONCLUSIONS: Our data suggest that HHcy and MS could work together in increasing CVD risk. FAU - Bellia, Chiara AU - Bellia C AD - Department of Medical Biotechnologies and Forensic Medicine, Faculty of Medicine, University of Palermo Italy. FAU - Bivona, Giulia AU - Bivona G FAU - Scazzone, Concetta AU - Scazzone C FAU - Ciaccio, Marcello AU - Ciaccio M LA - eng PT - Journal Article PL - New Zealand TA - Ther Clin Risk Manag JT - Therapeutics and clinical risk management JID - 101253281 PMC - PMC2387296 OTO - NOTNLM OT - cardiovascular disease OT - homocysteine OT - metabolic syndrome EDAT- 2008/06/03 09:00 MHDA- 2008/06/03 09:01 PMCR- 2008/04/01 CRDT- 2008/06/03 09:00 PHST- 2008/06/03 09:00 [pubmed] PHST- 2008/06/03 09:01 [medline] PHST- 2008/06/03 09:00 [entrez] PHST- 2008/04/01 00:00 [pmc-release] PST - ppublish SO - Ther Clin Risk Manag. 2007 Dec;3(6):999-1001.