PMID- 18516930
OWN - NLM
STAT- MEDLINE
DCOM- 20080701
LR  - 20220317
IS  - 0018-2052 (Print)
IS  - 0018-2052 (Linking)
VI  - 56
IP  - 3-4
DP  - 2007 Dec
TI  - The mRNA expression of neurotrophins in different skeletal muscles of young rats.
PG  - 23-8
AB  - Skeletal muscles are a target for motoneurons and synthesize neurotrophins, 
      including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), 
      neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5). Both at the embryonic stage 
      and the adult stage, the mRNA expression of neurotrophins in skeletal muscles of 
      rats has been reported. However, little was known about the mRNA expression 
      patterns of neurotrophins in skeletal muscles of rats at the young developmental 
      stage. In this study, we investigated the mRNA expressions of BDNF and NT-3 in 
      three different skeletal muscles in 4- to 8- week-old rats using the reverse 
      transcriptional polymerase chain reaction (RT-PCR) method. The expression of BDNF 
      mRNA in the soleus muscle gradually became higher with age from 5 to 8 weeks. But 
      BDNF mRNA in the tibialis anterior and extensor digitorum longus muscles did not 
      change with growth. The expression of NT-3 mRNA did not show a specific tendency 
      during this period. The differences of muscle fiber types, recruitment patterns 
      of the muscles, and roles of neurotrophins may cause these mRNA expression 
      patterns. Neurotrophins are target-derived, activity-dependent neurotrophic 
      factors and are transported retrogradely. There is a possibility that the 
      different expression patterns of neurotrophins in muscles may be involved in the 
      maturation of neuromuscular function in different muscles during the young 
      developmental period.
FAU - Saka, Yukari
AU  - Saka Y
AD  - Graduate School of Health Sciences, Hiroshima University, Hiroshima 734-8551, 
      Japan. sakayukari@hiroshima-u.ac.jp
FAU - Yoshimura, Osamu
AU  - Yoshimura O
FAU - Tahara, Hidetoshi
AU  - Tahara H
FAU - Takeda, Yayoi
AU  - Takeda Y
FAU - Moriyama, Hideki
AU  - Moriyama H
FAU - Maejima, Hiroshi
AU  - Maejima H
FAU - Tobimatsu, Yoshiko
AU  - Tobimatsu Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Hiroshima J Med Sci
JT  - Hiroshima journal of medical sciences
JID - 0421060
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Muscle, Skeletal/*metabolism
MH  - Neurotrophin 3/*genetics
MH  - RNA, Messenger/*analysis
MH  - Rats
MH  - Rats, Wistar
EDAT- 2008/06/04 09:00
MHDA- 2008/07/02 09:00
CRDT- 2008/06/04 09:00
PHST- 2008/06/04 09:00 [pubmed]
PHST- 2008/07/02 09:00 [medline]
PHST- 2008/06/04 09:00 [entrez]
PST - ppublish
SO  - Hiroshima J Med Sci. 2007 Dec;56(3-4):23-8.