PMID- 18517045
OWN - NLM
STAT- MEDLINE
DCOM- 20080717
LR  - 20211020
IS  - 0161-8105 (Print)
IS  - 1550-9109 (Electronic)
IS  - 0161-8105 (Linking)
VI  - 31
IP  - 5
DP  - 2008 May
TI  - MX2 gene expression tends to be downregulated in subjects with HLA-DQB1*0602.
PG  - 749-51
AB  - OBJECTIVE: There is a close association between narcolepsy and the human 
      leukocyte antigen (HLA)-DQB1*0602. The detailed influence and function of this 
      specific HLA allele with regard to narcolepsy have not yet been elucidated. Our 
      previous report identified the myxovirus resistance 2 (MX2) gene as a 
      narcolepsy-specific dysregulated gene; however, the report had a limitation-the 
      control groups were not HLA matched. In this study, we examined the possibility 
      of an association between MX2 expression and HLA haplotypes. DESIGNS: The 
      expression levels of the MX2 gene in 3 groups (24 narcolepsy with cataplexy 
      patients; 24 age-, sex-, and HLA-DQB1 genotype-matched controls; and 24 age- and 
      sex-matched controls without the HLA-DQB1*0602 allele) were measured by 
      quantitative real-time RT-PCR. RESULTS: The expression level of the MX2 gene 
      tended to be downregulated in subjects carrying HLA-DQB1*0602, compared with that 
      of the control subjects without this allele. There was no difference in the MX2 
      expression level between the narcolepsy subjects and the HLA-DQB1 
      genotype-matched control subjects. CONCLUSION: Our previous finding-the 
      narcolepsy-specific reduction of MX2 gene expression-was not replicated in this 
      follow-up study. The expression level of the MX2 gene in white blood cells was 
      found to be lower in subjects with the HLA-DQB1*0602 than in subjects without 
      this allele, suggesting that there exists a relationship between the 
      HLA-DQB1*0602 allele and MX2 gene expression. This might be a possible 
      explanation for the strong HLA association observed in narcolepsy.
FAU - Tanaka, Susumu
AU  - Tanaka S
AD  - Sleep Disorders Project, Department of Sleep Disorders Research, Tokyo Institute 
      of Psychiatry, Setagaya-ku, Tokyo, Japan.
FAU - Honda, Yutaka
AU  - Honda Y
FAU - Honda, Makoto
AU  - Honda M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Myxovirus Resistance Proteins)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Cataplexy/*genetics
MH  - Down-Regulation/*genetics
MH  - Female
MH  - GTP-Binding Proteins/*genetics
MH  - Genetic Carrier Screening
MH  - *Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - Myxovirus Resistance Proteins
MH  - Narcolepsy/*genetics
MH  - Reproducibility of Results
MH  - Reverse Transcriptase Polymerase Chain Reaction
PMC - PMC2398745
EDAT- 2008/06/04 09:00
MHDA- 2008/07/18 09:00
PMCR- 2008/11/01
CRDT- 2008/06/04 09:00
PHST- 2008/06/04 09:00 [pubmed]
PHST- 2008/07/18 09:00 [medline]
PHST- 2008/06/04 09:00 [entrez]
PHST- 2008/11/01 00:00 [pmc-release]
AID - 10.1093/sleep/31.5.749 [doi]
PST - ppublish
SO  - Sleep. 2008 May;31(5):749-51. doi: 10.1093/sleep/31.5.749.