PMID- 18518880
OWN - NLM
STAT- MEDLINE
DCOM- 20090116
LR  - 20151119
IS  - 1440-1681 (Electronic)
IS  - 0305-1870 (Linking)
VI  - 35
IP  - 9
DP  - 2008 Sep
TI  - Central choline suppresses plasma renin response to graded haemorrhage in rats.
PG  - 1023-31
LID - 10.1111/j.1440-1681.2008.04978.x [doi]
AB  - Central administration of choline increases blood pressure in normotensive and 
      hypotensive states by increasing plasma concentrations of vasopressin and 
      catecholamines. We hypothesized that choline could also modulate the 
      renin-angiotensin pathway, the third main pressor system in the body. Plasma 
      renin activity (PRA), which serves as an index of the function of the peripheral 
      renin-angiotensin system, was determined in rats subjected to graded haemorrhage 
      following central choline administration. Intracerebroventricular (i.c.v.) 
      injection of choline (12.5-150 microg), a precursor of the neurotransmitter 
      acetylcholine (ACh), inhibited the increase in PRA in rats subjected to graded 
      haemorrhage by sequential removal of 0.55 mL blood/100 g bodyweight. Choline, in 
      the range 50-150 microg, increased blood pressure. Intraperitoneal (i.p.) 
      administration of 150 microg choline failed to alter blood pressure and plasma 
      renin responses to graded haemorrhage. Administration of a higher dose (90 mg/kg, 
      i.p.) of choline decreased blood pressure and enhanced PRA in the first two blood 
      samples obtained during the graded haemorrhage. Physostigmine (10 microg, 
      i.c.v.), ACh (10 microg, i.c.v.), carbamylcholine (10 microg, i.c.v.) and 
      cytidine 5'-diphosphocholine (CDP-choline; 250 microg, i.c.v.) increased blood 
      pressure and attenuated plasma renin responses to graded haemorrhage. Inhibition 
      of PRA by i.c.v. choline was abolished by i.c.v. pretreatment with mecamylamine 
      (50 microg), but not atropine (10 microg). Blood pressure responses to choline 
      (150 microg) were attenuated by pretreatment with both mecamylamine and atropine. 
      Inhibition of PRA in response to central choline administration was associated 
      with enhanced plasma vasopressin and catecholamine responses to graded 
      haemorrhage. Pretreatment of rats with a vasopressin antagonist reversed central 
      choline-induced inhibition of plasma renin responses to graded haemorrhage 
      without altering the blood pressure response. In conclusion, central 
      administration of choline inhibits the plasma renin response to graded 
      haemorrhage. Nicotinic receptor activation and an increase in plasma vasopressin 
      appear to be involved in this effect.
FAU - Isbil-Buyukcoskun, Naciye
AU  - Isbil-Buyukcoskun N
AD  - Department of Physiology, Uludag University Medical School, Bursa, Turkey.
FAU - Ilcol, Yesim O
AU  - Ilcol YO
FAU - Cansev, Mehmet
AU  - Cansev M
FAU - Hamurtekin, Emre
AU  - Hamurtekin E
FAU - Ozluk, Kasim
AU  - Ozluk K
FAU - Ulus, Ismail H
AU  - Ulus IH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080601
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Cholinergic Agonists)
RN  - 0 (Cholinesterase Inhibitors)
RN  - 11000-17-2 (Vasopressins)
RN  - 536BQ2JVC7 (Cytidine Diphosphate Choline)
RN  - 6EE945D3OK (Mecamylamine)
RN  - 8Y164V895Y (Carbachol)
RN  - 9U1VM840SP (Physostigmine)
RN  - EC 3.4.23.15 (Renin)
RN  - N91BDP6H0X (Choline)
SB  - IM
MH  - Animals
MH  - Antihypertensive Agents/pharmacology
MH  - Blood Pressure/drug effects
MH  - Carbachol/administration & dosage/pharmacology
MH  - Choline/administration & dosage/*pharmacology
MH  - Cholinergic Agonists/administration & dosage/pharmacology
MH  - Cholinesterase Inhibitors/administration & dosage/pharmacology
MH  - Cytidine Diphosphate Choline/administration & dosage/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Female
MH  - Hemorrhage/blood/metabolism/pathology/*physiopathology
MH  - Injections, Intraventricular
MH  - Mecamylamine/pharmacology
MH  - Periodicity
MH  - Physostigmine/administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Renin/*blood/metabolism
MH  - Renin-Angiotensin System/*drug effects/physiology
MH  - Vasopressins/blood
EDAT- 2008/06/04 09:00
MHDA- 2009/01/17 09:00
CRDT- 2008/06/04 09:00
PHST- 2008/06/04 09:00 [pubmed]
PHST- 2009/01/17 09:00 [medline]
PHST- 2008/06/04 09:00 [entrez]
AID - CEP4978 [pii]
AID - 10.1111/j.1440-1681.2008.04978.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 2008 Sep;35(9):1023-31. doi: 
      10.1111/j.1440-1681.2008.04978.x. Epub 2008 Jun 1.