PMID- 18518883
OWN - NLM
STAT- MEDLINE
DCOM- 20090619
LR  - 20081028
IS  - 1440-1681 (Electronic)
IS  - 0305-1870 (Linking)
VI  - 35
IP  - 10
DP  - 2008 Oct
TI  - Short-term treatment of stroke-prone spontaneously hypertensive rats with an AT1 
      receptor blocker protects against hypertensive end-organ damage by prolonged 
      inhibition of the renin-angiotensin system.
PG  - 1151-5
LID - 10.1111/j.1440-1681.2008.04973.x [doi]
AB  - The aim of the present study was to investigate the effects of short-term 
      treatment with an AT(1) receptor blocker (ARB) on amelioration of hypertensive 
      end-organ damage in stroke-prone spontaneously hypertensive rats (SHRSP). Male 
      SHRSP were divided into two groups: (i) an ARB-treated group; and (ii) a control 
      group. Candesartan (1 mg/kg per day) was administered orally from 6 to 11 weeks 
      of age. At 20 weeks of age, plasma renin activity (PRA), angiotensin II 
      concentrations, angiotensin-converting enzyme (ACE) activity and hydroperoxide 
      content were measured. Expression of intercellular adhesion molecule (ICAM)-1, 
      renin, AT(1) and AT(2) receptors was investigated by reverse 
      transcription-polymerase chain reaction. Blood pressure in the ARB group was 
      slightly lower at 7, 8, 11, 13-15 and 18 weeks of age, but no significant 
      difference in blood pressure was found between the ARB and control groups at 20 
      weeks of age. All rats in the control group had cerebral oedema, whereas no 
      lesions were found in the ARB group. In the ARB group, PRA, AII and hydroperoxide 
      content were lower than in the control group. In the ARB-treated group, lower 
      ICAM-1 expression was found in the cerebral cortex and slightly, albeit not 
      significantly, lower expression of renin was found in the kidney. In contrast, 
      AT(1) receptor expression in the cerebrum and kidney was higher in the ARB group 
      compared with the control group. These results indicate that short-term treatment 
      of SHRSP with ARB at a young age is effective in preventing cerebral oedema after 
      maturation. Such beneficial effects of ARB may be due, in part, to decreased 
      blood pressure and is likely mainly due to inhibition of total circulating and 
      local renin-angiotensin systems.
FAU - Hamaguchi, Rika
AU  - Hamaguchi R
AD  - Department of Pathology, Kinki University School of Medicine, Osaka, Japan.
FAU - Takemori, Kumiko
AU  - Takemori K
FAU - Inoue, Takao
AU  - Inoue T
FAU - Masuno, Kouichi
AU  - Masuno K
FAU - Ito, Hiroyuki
AU  - Ito H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20080601
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Receptor, Angiotensin, Type 1)
SB  - IM
MH  - Angiotensin II Type 1 Receptor Blockers/pharmacology/*therapeutic use
MH  - Animals
MH  - Blood Pressure/drug effects/physiology
MH  - Brain Edema/metabolism/physiopathology/prevention & control
MH  - Hypertension/metabolism/*physiopathology/*prevention & control
MH  - Kidney Function Tests
MH  - Male
MH  - Oxidative Stress/drug effects/physiology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Receptor, Angiotensin, Type 1/*metabolism
MH  - Renin-Angiotensin System/*drug effects/physiology
MH  - Stroke/metabolism/*physiopathology/*prevention & control
MH  - Time Factors
EDAT- 2008/06/04 09:00
MHDA- 2009/06/20 09:00
CRDT- 2008/06/04 09:00
PHST- 2008/06/04 09:00 [pubmed]
PHST- 2009/06/20 09:00 [medline]
PHST- 2008/06/04 09:00 [entrez]
AID - CEP4973 [pii]
AID - 10.1111/j.1440-1681.2008.04973.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 2008 Oct;35(10):1151-5. doi: 
      10.1111/j.1440-1681.2008.04973.x. Epub 2008 Jun 1.