PMID- 18519231
OWN - NLM
STAT- MEDLINE
DCOM- 20080804
LR  - 20161020
IS  - 1897-5631 (Electronic)
IS  - 0239-8508 (Linking)
VI  - 46
IP  - 2
DP  - 2008
TI  - Naive helper T cells from BCG-vaccinated volunteers produce IFN-gamma and IL-5 to 
      mycobacterial antigen-pulsed dendritic cells.
PG  - 153-7
LID - 10.2478/v10042-008-0023-6 [doi]
AB  - Mycobacterium bovis bacillus Calmette-Guerin (BCG) is a live vaccine that has 
      been used in routine vaccination against tuberculosis for nearly 80 years. 
      However, its efficacy is controversial. The failure of BCG vaccination may be at 
      least partially explained by the induction of poor or inappropriate host 
      responses. Dendritic cells (DCs) are likely to play a key role in the induction 
      of immune response to mycobacteria by polarizing the reactivity of T lymphocytes 
      toward a Th1 profile, contributing to the generation of protective cellular 
      immunity against mycobacteria. In this study we aimed to investigate the 
      production of Th1 and Th2 cytokines by naive CD4+ T cells to mycobacterial 
      antigen-pulsed DCs in the group of young, healthy BCG vaccinated volunteers. The 
      response of naive helper T cells was compared with the response of total blood 
      lymphocytes. Our present results clearly showed that circulating naive 
      CD45RA+CD4+ lymphocytes from BCG-vaccinated subjects can become effector helper 
      cells producing IFN-gamma and IL-5 under the stimulation by autologous dendritic 
      cells presenting mycobacterial protein antigen-PPD or infected with live M. bovis 
      BCG bacilli.
FAU - Kowalewicz-Kulbat, Magdalena
AU  - Kowalewicz-Kulbat M
AD  - Department of Immunology and Infectious Biology, University of Lodz, Poland.
FAU - Kazmierczak, Dominik
AU  - Kazmierczak D
FAU - Donevski, Stefan
AU  - Donevski S
FAU - Biet, Franck
AU  - Biet F
FAU - Pestel, Joel
AU  - Pestel J
FAU - Rudnicka, Wieslawa
AU  - Rudnicka W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Folia Histochem Cytobiol
JT  - Folia histochemica et cytobiologica
JID - 8502651
RN  - 0 (Antigens, Bacterial)
RN  - 0 (BCG Vaccine)
RN  - 0 (Interleukin-5)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tuberculin)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Antigens, Bacterial/*immunology
MH  - BCG Vaccine/*immunology/pharmacology
MH  - Dendritic Cells/drug effects/*immunology
MH  - Humans
MH  - Interferon-gamma/*biosynthesis
MH  - Interleukin-5/*biosynthesis
MH  - Lipopolysaccharides/pharmacology
MH  - Mycobacterium/drug effects/*immunology
MH  - T-Lymphocytes, Helper-Inducer/drug effects/*immunology
MH  - Tuberculin/immunology/pharmacology
MH  - Vaccination
EDAT- 2008/06/04 09:00
MHDA- 2008/08/05 09:00
CRDT- 2008/06/04 09:00
PHST- 2008/06/04 09:00 [pubmed]
PHST- 2008/08/05 09:00 [medline]
PHST- 2008/06/04 09:00 [entrez]
AID - 6845LP6457383513 [pii]
AID - 10.2478/v10042-008-0023-6 [doi]
PST - ppublish
SO  - Folia Histochem Cytobiol. 2008;46(2):153-7. doi: 10.2478/v10042-008-0023-6.