PMID- 18520158
OWN - NLM
STAT- MEDLINE
DCOM- 20081007
LR  - 20080915
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 147
IP  - 2
DP  - 2008
TI  - HLA class I and class II genotyping in patients with chronic urticaria.
PG  - 135-9
LID - 10.1159/000135700 [doi]
AB  - OBJECTIVES: Chronic urticaria (CU) is a common disease in which pathogenesis is 
      unclear and which is resistant to therapy. Recent investigations have indicated 
      that autoimmunity plays a role in nearly one third of CU patients. The present 
      study aimed to investigate the relationship between human leukocyte antigen (HLA) 
      class I and class II antigens and immune pathogenesis of CU. METHODS: HLA class I 
      and class II antigens were investigated in 40 patients diagnosed with CU, 
      utilizing serologic techniques and polymerase chain reactions. The study was 
      performed between October 2005 and May 2006. Further HLA typing in patient 
      subsets was done depending on the response of patients to intradermal injection 
      of autologous serum. About 30 healthy and genetically unrelated individuals 
      formed the control group for evaluation. RESULTS: The results revealed that 
      HLA-B44 frequency was significantly higher (25%) in the patient group as compared 
      with the matched control group (3.33%) (p = 0.033, OR = 9.667). There was no 
      significant difference in HLA-A allelic distribution between the patient and 
      control groups. In the genotyping of class II HLA alleles, HLA-DRB1*01 (25%) (p = 
      0.033, OR = 9.667) and HLA-DRB*15 (25%) (p = 0.033, OR = 9.667) were predominant 
      alleles in the patient group. CONCLUSION: The association of HLA-B44, HLA-DRB1*01 
      and HLA-DRB*15 alleles with idiopathic CU suggests that there is a genetic 
      component in the pathogenesis of CU.
CI  - (c) 2008 S. Karger AG, Basel.
FAU - Coban, Muge
AU  - Coban M
AD  - Dermatology Section, Rize State Hospital, Rize, Turkey.
FAU - Erdem, Teoman
AU  - Erdem T
FAU - Ozdemir, Sevki
AU  - Ozdemir S
FAU - Pirim, Ibrahim
AU  - Pirim I
FAU - Atasoy, Mustafa
AU  - Atasoy M
FAU - Ikbal, Mevlit
AU  - Ikbal M
LA  - eng
PT  - Journal Article
DEP - 20080603
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chronic Disease
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Turkey/epidemiology
MH  - Urticaria/epidemiology/*genetics
EDAT- 2008/06/04 09:00
MHDA- 2008/10/08 09:00
CRDT- 2008/06/04 09:00
PHST- 2007/07/10 00:00 [received]
PHST- 2008/01/30 00:00 [accepted]
PHST- 2008/06/04 09:00 [pubmed]
PHST- 2008/10/08 09:00 [medline]
PHST- 2008/06/04 09:00 [entrez]
AID - 000135700 [pii]
AID - 10.1159/000135700 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2008;147(2):135-9. doi: 10.1159/000135700. Epub 2008 
      Jun 3.