PMID- 18521456
OWN - NLM
STAT- MEDLINE
DCOM- 20080926
LR  - 20161124
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 29
IP  - 6
DP  - 2008 Jun
TI  - Hemochromatosis gene (HFE) mutations in patients with type 2 diabetes and their 
      control group in an Iranian population.
PG  - 808-12
AB  - OBJECTIVE: To assess the frequency of 2 different forms of hemochromatosis HFE 
      gene mutations (C282Y and H63D mutations) in a normal population in comparison 
      with type 2 diabetic patients. METHODS: This case control study was undertaken in 
      Zanjan Diabetic Care Center, Zanjan, western Tehran, in 2005. Two hundred and two 
      individuals were included in this study: 101 type 2 diabetes mellitus (T2DM) 
      patients, and 101 age, and gender-matched controls. The patients were examined 
      for mutations in the HFE gene. Nucleotide 845 (C282Y) and 187 (H63D) alleles were 
      amplified by polymerase chain reaction PCR with lymphocyte deoxy-ribonucleic 
      acid. The PCR products were analyzed by restriction enzyme digestion. Chi-square, 
      student's t test, and Fisher's exact tests were used for comparison, and odds' 
      ratio was calculated. RESULTS: Two hundred and two individuals were studied. The 
      frequency of wild/C282Y alleles was 98/2% in T2DM patients, and 99/1% in controls 
      p=0.6. The frequency of wild/H63D alleles was 68.3/31.7% in diabetics p=0.08, and 
      73.4/26.3% in control subjects p=0.08. The distribution of genotypes was not 
      statistically different. CONCLUSION: Based on our data, HFE mutations were not 
      found in excess in patients with T2DM, and there was no evidence that a 
      population-based search for an excess of these alleles in type 2 diabetes was 
      indicated.
FAU - Sharifi, Faranak
AU  - Sharifi F
AD  - Department of Endocrinology, Vali-e-asr Hospital, Zanjan Metabolic Diseases 
      Research Center, Zanjan, Iran. faranaksharifi@hotmail.com
FAU - Esmaeilzadeh, Abdulreza
AU  - Esmaeilzadeh A
FAU - Zali, Mohammadreza
AU  - Zali M
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
RN  - 0 (HFE protein, human)
RN  - 0 (Hemochromatosis Protein)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Hemochromatosis Protein
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Iran
MH  - Male
MH  - Membrane Proteins/*genetics
MH  - Middle Aged
MH  - Mutation
MH  - Polymerase Chain Reaction
EDAT- 2008/06/04 09:00
MHDA- 2008/09/27 09:00
CRDT- 2008/06/04 09:00
PHST- 2008/06/04 09:00 [pubmed]
PHST- 2008/09/27 09:00 [medline]
PHST- 2008/06/04 09:00 [entrez]
AID - 20080037' [pii]
PST - ppublish
SO  - Saudi Med J. 2008 Jun;29(6):808-12.