PMID- 18521701
OWN - NLM
STAT- MEDLINE
DCOM- 20090127
LR  - 20220408
IS  - 0960-8923 (Print)
IS  - 0960-8923 (Linking)
VI  - 18
IP  - 9
DP  - 2008 Sep
TI  - Type 2 diabetes mellitus and the metabolic syndrome following sleeve gastrectomy 
      in severely obese subjects.
PG  - 1077-82
LID - 10.1007/s11695-008-9547-2 [doi]
AB  - BACKGROUND: Data on the effectiveness of sleeve gastrectomy in improving or 
      resolving type 2 diabetes mellitus (T2DM) and the metabolic syndrome (MS) are 
      scarce. METHODS: A twelve-month prospective study on the changes in glucose 
      homeostasis and the MS in 91 severely obese T2DM subjects undergoing laparoscopic 
      SG (SG; n = 39) or laparoscopic Roux-en-Y gastric bypass (GBP; n = 52), matched 
      for DM duration, type of DM treatment, and glycemic control was conducted. 
      RESULTS: At 12 months after surgery, subjects undergoing SG and GBP lost a 
      similar amount of weight (%EBL: SG: 63.00 +/- 2.89%, BPG: 66.06 +/- 2.34%; p = 
      0.413). On that evaluation, T2DM had resolved, respectively, in 33 out of 39 
      (84.6%) and 44 out of 52 (84.6%) subjects after SG and GBP (p = 0.618). The rate 
      of resolution of the MS (SG: 62.2%, BPG: 67.3%; p = 0.392) was also comparable. A 
      shorter DM duration (p < 0.05), a DM treatment not including pharmacological 
      agents (p < 0.05), and a better glycemic control (p < 0.05), were significantly 
      associated with T2DM resolution in both surgical groups. Weight loss was not 
      associated with T2DM resolution after SG or GBP, but was associated with 
      resolution of the MS following the two surgical procedures (p < 0.05). 
      CONCLUSIONS: Our data show that at 12 months after surgery, SG is as effective as 
      GBP in inducing remission of T2DM and the MS. Furthermore, our data suggest that 
      SG and GBP represent a successful an integrated strategy for the management of 
      the different cardiovascular risk components of the MS in subjects with T2DM.
FAU - Vidal, J
AU  - Vidal J
AD  - Obesity Unit, Hospital Clinic Universitari, Villarroel 170, Barcelona, Spain. 
      jovidal@clinic.ub.es
FAU - Ibarzabal, A
AU  - Ibarzabal A
FAU - Romero, F
AU  - Romero F
FAU - Delgado, S
AU  - Delgado S
FAU - Momblan, D
AU  - Momblan D
FAU - Flores, L
AU  - Flores L
FAU - Lacy, A
AU  - Lacy A
LA  - eng
PT  - Clinical Conference
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080603
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/complications/metabolism/*prevention & control
MH  - Female
MH  - Follow-Up Studies
MH  - *Gastrectomy
MH  - *Gastric Bypass
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/complications/metabolism/*prevention & control
MH  - Middle Aged
MH  - Obesity, Morbid/complications/metabolism/*surgery
MH  - Time Factors
MH  - Treatment Outcome
MH  - Weight Loss
EDAT- 2008/06/04 09:00
MHDA- 2009/01/28 09:00
CRDT- 2008/06/04 09:00
PHST- 2008/04/09 00:00 [received]
PHST- 2008/04/30 00:00 [accepted]
PHST- 2008/06/04 09:00 [pubmed]
PHST- 2009/01/28 09:00 [medline]
PHST- 2008/06/04 09:00 [entrez]
AID - 10.1007/s11695-008-9547-2 [doi]
PST - ppublish
SO  - Obes Surg. 2008 Sep;18(9):1077-82. doi: 10.1007/s11695-008-9547-2. Epub 2008 Jun 
      3.