PMID- 18521763
OWN - NLM
STAT- MEDLINE
DCOM- 20081015
LR  - 20211020
IS  - 0893-7648 (Print)
IS  - 0893-7648 (Linking)
VI  - 37
IP  - 2-3
DP  - 2008 Apr-Jun
TI  - Neurosteroids in the Purkinje cell: biosynthesis, mode of action and functional 
      significance.
PG  - 116-25
LID - 10.1007/s12035-008-8024-1 [doi]
AB  - Neurosteroids are synthesized de novo from cholesterol in the brain. To 
      understand neurosteroid action in the brain, data on the regio- and 
      temporal-specific synthesis of neurosteroids are needed. Recently the Purkinje 
      cell, an important cerebellar neuron, has been identified as a major site for 
      neurosteroid formation in vertebrates. This is the first demonstration of de novo 
      neuronal neurosteroidogenesis in the brain. Since this discovery, organizing 
      actions of neurosteroids are becoming clear by the studies using the Purkinje 
      cell as an excellent cellular model. In mammals, the Purkinje cell actively 
      synthesizes progesterone and estradiol de novo from cholesterol during neonatal 
      life. Both progesterone and estradiol promote dendritic growth, spinogenesis, and 
      synaptogenesis via each cognate nuclear receptor in the developing Purkinje cell. 
      Such organizing actions that may be mediated by neurotrophic factors, such as 
      brain-derived neurotrophic factor (BDNF), contribute to the formation of 
      cerebellar neuronal circuit during neonatal life. Allopregnanolone, a 
      progesterone metabolite, is also synthesized in the cerebellum and acts on 
      Purkinje cell survival in the neonate. This review summarizes the advances made 
      in our understanding of the biosynthesis, mode of action and functional 
      significance of neurosteroids in the Purkinje cell.
FAU - Tsutsui, Kazuyoshi
AU  - Tsutsui K
AD  - Laboratory of Integrative Brain Sciences, Department of Biology, Faculty of 
      Education and Integrated Arts and Sciences, Waseda University, 2-2 Wakamatsu-cho, 
      Shinjuku-ku, Tokyo 162-8480, Japan. k-tsutsui@waseda.jp
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080603
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 73R90F7MQ8 (Pregnenolone)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - BXO86P3XXW (Pregnanolone)
SB  - IM
MH  - Animals
MH  - Cholesterol/chemistry/metabolism
MH  - Estradiol/metabolism
MH  - Molecular Structure
MH  - Pregnanolone/chemistry/metabolism
MH  - Pregnenolone/chemistry/*metabolism
MH  - Progesterone/chemistry/*metabolism
MH  - Purkinje Cells/cytology/*metabolism
RF  - 97
EDAT- 2008/06/04 09:00
MHDA- 2008/10/16 09:00
CRDT- 2008/06/04 09:00
PHST- 2008/02/23 00:00 [received]
PHST- 2008/04/25 00:00 [accepted]
PHST- 2008/06/04 09:00 [pubmed]
PHST- 2008/10/16 09:00 [medline]
PHST- 2008/06/04 09:00 [entrez]
AID - 10.1007/s12035-008-8024-1 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2008 Apr-Jun;37(2-3):116-25. doi: 10.1007/s12035-008-8024-1. Epub 
      2008 Jun 3.