PMID- 18522713
OWN - NLM
STAT- MEDLINE
DCOM- 20090904
LR  - 20101118
IS  - 1751-5521 (Print)
IS  - 1751-5521 (Linking)
VI  - 30
IP  - 6
DP  - 2008 Dec
TI  - T-cell precursor frequencies and long-term outcome following unrelated 
      hematopoietic stem cell transplantation.
PG  - 499-507
LID - 10.1111/j.1751-553X.2007.00990.x [doi]
AB  - Functional assays measuring alloreactivity of donor cells are desired to detect 
      either cryptic epitopes inducing graft-vs.-host disease (GvHD) after human 
      leukocyte antigen (HLA)-identical hematopoietic stem cell transplantation (HSCT) 
      or permissible HLA mismatches. However, their value in predicting GvHD and 
      survival is still limited. We determined the cytotoxic and helper T-cell 
      precursor (CTLp and HTLp) frequencies by limiting dilution analysis (LDA) in 40 
      unrelated recipient/donor combinations. The median observation period at the time 
      of this writing was 4.44 years (range from 0.1 to 11.28). Better overall survival 
      was observed in patients with rather low host-specific CTLp and HTLp frequencies, 
      whereas a trend toward high CTLp frequencies was seen in patients with higher 
      incidence of acute GvHD, especially in patients mismatched in HLA-C. CTLp and 
      HTLp frequencies did not correlate with the incidence of chronic GvHD and 
      relapse. In conclusion, we detected a trend toward better overall survival of 
      patient/donor pairs with low CTLp and HTLp frequencies, however, recommend to use 
      LDA as an additional tool for identifying the most suitable donor when more than 
      one fully HLA-matched stem cell donor is available.
FAU - Kircher, B
AU  - Kircher B
FAU - Niederwieser, D
AU  - Niederwieser D
FAU - Gachter, A
AU  - Gachter A
FAU - Lindner, B
AU  - Lindner B
FAU - Mitterschiffthaler, A
AU  - Mitterschiffthaler A
FAU - Urban, C
AU  - Urban C
FAU - Greinix, H
AU  - Greinix H
FAU - Peters, C
AU  - Peters C
FAU - Latzer, K
AU  - Latzer K
FAU - Gastl, G
AU  - Gastl G
FAU - Nachbaur, D
AU  - Nachbaur D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Lab Hematol
JT  - International journal of laboratory hematology
JID - 101300213
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Graft vs Host Disease/immunology/*mortality
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Infant
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Precursor Cells, T-Lymphoid/*immunology
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - T-Lymphocytes, Helper-Inducer/*immunology
MH  - Young Adult
EDAT- 2008/06/05 09:00
MHDA- 2009/09/05 06:00
CRDT- 2008/06/05 09:00
PHST- 2008/06/05 09:00 [pubmed]
PHST- 2009/09/05 06:00 [medline]
PHST- 2008/06/05 09:00 [entrez]
AID - CLH0990 [pii]
AID - 10.1111/j.1751-553X.2007.00990.x [doi]
PST - ppublish
SO  - Int J Lab Hematol. 2008 Dec;30(6):499-507. doi: 10.1111/j.1751-553X.2007.00990.x.