PMID- 18523912
OWN - NLM
STAT- MEDLINE
DCOM- 20090619
LR  - 20081121
IS  - 0947-7349 (Print)
IS  - 0947-7349 (Linking)
VI  - 116
IP  - 9
DP  - 2008 Oct
TI  - Lymph node gastrinoma in multiple endocrine neoplasia type 1 - a diagnostic 
      challenge.
PG  - 554-7
LID - 10.1055/s-2008-1062727 [doi]
AB  - BACKGROUND: Gastrinomas are the most frequent hormonally-active neuroendocrine 
      tu-mours in patients with multiple endocrine neoplasia type 1 (MEN1). CASE 
      REPORT: We report on the diagnostic difficulties in a 62-year-old female patient 
      with MEN1 and lymph node gastrinoma. At six and twelve months after resection of 
      a lymph node gastrinoma, no signs of recurrence were observed. Basal and peak 
      gastrin levels during secretin stimulation test were normalized. Extensive 
      explorations, including gastrointesinal endoscopy, endoscopic ultrasonography, 
      and Ga-68-DOTATOC-PET/CT, did not reveal a primary duodenal or pancreatic tumour. 
      CONCLUSION: Localization of gastrinomas in patients with MEN1 is challenging due 
      to their small size, frequent duodenal location, and multiplicity. Therefore, 
      while some studies support the existence of primary lymph node gastrinoma in 
      patients with sporadic disease, this diagnosis should not be made in MEN1 
      patients. In both cases, however, extensive follow-ups are required.
FAU - Mussig, K
AU  - Mussig K
AD  - Division of Endocrinology, Diabetology, Nephrology, Angiology, and Clinical 
      Chemistry, Department of Internal Medicine, University Hospital of Tubingen, 
      Tubingen, Germany. Karsten.Muessig@med.uni-tuebingen.de
FAU - Wehrmann, M
AU  - Wehrmann M
FAU - Horger, M
AU  - Horger M
FAU - Bares, R
AU  - Bares R
FAU - Haring, H-U
AU  - Haring HU
FAU - Gallwitz, B
AU  - Gallwitz B
FAU - Petersenn, S
AU  - Petersenn S
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20080401
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
SB  - IM
MH  - Diarrhea/etiology
MH  - Duodenal Ulcer/pathology
MH  - Esophagitis/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Gastrinoma/*pathology/surgery
MH  - Gastritis/pathology
MH  - Humans
MH  - Lymph Nodes/*pathology/surgery
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*pathology/surgery
MH  - Treatment Outcome
EDAT- 2008/06/05 09:00
MHDA- 2009/06/20 09:00
CRDT- 2008/06/05 09:00
PHST- 2008/06/05 09:00 [pubmed]
PHST- 2009/06/20 09:00 [medline]
PHST- 2008/06/05 09:00 [entrez]
AID - 10.1055/s-2008-1062727 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2008 Oct;116(9):554-7. doi: 10.1055/s-2008-1062727. 
      Epub 2008 Apr 1.