PMID- 18525219
OWN - NLM
STAT- MEDLINE
DCOM- 20080819
LR  - 20170124
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 29
IP  - 2
DP  - 2008
TI  - Association of CCL2 with lymph node metastasis and macrophage infiltration in 
      oral cavity and lip squamous cell carcinoma.
PG  - 114-21
LID - 10.1159/000137669 [doi]
AB  - AIMS/METHODS: We investigated the expression of CCL2 by immunohistochemistry in 
      samples of oral cavity squamous cell carcinoma (OCSCC), lip squamous cell 
      carcinoma (LSCC) and metastatic and nonmetastatic lymph nodes. The relationship 
      of CCL2 with survival data was also evaluated. RESULTS: The percentage of CCL2+ 
      cells in tumor parenchyma was similar in OCSCC and LSCC. In stroma, OCSCC showed 
      a higher number of CCL2+ cells when compared with LSCC. In contrast, higher CD68+ 
      macrophage counts were observed in LSCC. Low macrophage counts were significantly 
      related to a greater proliferative index in tumoral cells. The density of CCL2+ 
      nodal cells was significantly higher in metastatic lymph nodes when compared with 
      nonmetastatic lymph nodes. When considering CCL2 in the parenchyma, the mean 
      survival time for the patients with high CCL2+ cell counts was lower than that 
      for patients with low CCL2+ cell counts. In contrast, in stroma, the mean 
      survival time for the patients with high CCL2+ cell percentages was higher than 
      for those with low CCL2+ cell percentages. CONCLUSION: Our findings suggest a 
      role for CCL2 in the spreading of tumoral cells to the lymph node in OCSCC. 
      Furthermore, the CCL2-independent macrophage infiltration may play a role in 
      determining less aggressive behavior.
CI  - (c) 2008 S. Karger AG, Basel
FAU - Ferreira, Fernanda Oliveira
AU  - Ferreira FO
AD  - Department of Oral Surgery and Pathology, Dental School, Federal University of 
      Minas Gerais, Belo Horizonte, Brazil.
FAU - Ribeiro, Fernanda Luiza Leite
AU  - Ribeiro FL
FAU - Batista, Aline Carvalho
AU  - Batista AC
FAU - Leles, Claudio Rodrigues
AU  - Leles CR
FAU - de Cassia Goncalves Alencar, Rita
AU  - de Cassia Goncalves Alencar R
FAU - Silva, Tarcilia Aparecida
AU  - Silva TA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080605
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/genetics/*metabolism/pathology
MH  - Cell Movement/genetics/physiology
MH  - Chemokine CCL2/genetics/*metabolism
MH  - Disease Progression
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lip Neoplasms/genetics/*metabolism/pathology
MH  - Lymph Nodes/metabolism/pathology
MH  - Lymphatic Metastasis/genetics/*pathology
MH  - Macrophages/*pathology
MH  - Male
MH  - Mouth Neoplasms/genetics/*metabolism/pathology
MH  - Prognosis
EDAT- 2008/06/06 09:00
MHDA- 2008/08/20 09:00
CRDT- 2008/06/06 09:00
PHST- 2007/11/11 00:00 [received]
PHST- 2008/04/10 00:00 [accepted]
PHST- 2008/06/06 09:00 [pubmed]
PHST- 2008/08/20 09:00 [medline]
PHST- 2008/06/06 09:00 [entrez]
AID - 000137669 [pii]
AID - 10.1159/000137669 [doi]
PST - ppublish
SO  - Tumour Biol. 2008;29(2):114-21. doi: 10.1159/000137669. Epub 2008 Jun 5.