PMID- 18528638
OWN - NLM
STAT- MEDLINE
DCOM- 20100105
LR  - 20211020
IS  - 1573-2630 (Electronic)
IS  - 0165-5701 (Linking)
VI  - 29
IP  - 5
DP  - 2009 Oct
TI  - Recurrent giant chalazia in hyperimmunoglobulin E (Job's) syndrome.
PG  - 415-7
LID - 10.1007/s10792-008-9238-y [doi]
AB  - Hyperimmunoglobulinemia E (Job's) syndrome is a rare autosomal dominant disorder 
      appearing early in life with recurrent skin and pulmonary infections, 
      characterized by markedly increased serum immunoglobulin E (IgE) levels. We 
      describe a 50-year-old man with a 4-year history of recurrent, multiple giant 
      chalazia in all eyelids. Medications and surgical intervention had produced only 
      transient improvement. The patient had also had pulmonary and scalp infection. 
      Laboratory tests disclosed elevated serum IgE (>1,000 IU/ml) and eosinophilia. As 
      a result, based on the patient's history and clinical and laboratory findings, a 
      diagnosis of Job's syndrome was made. Even though rarely, recurrent multiple 
      giant chalazia may occur as an ophthalmic feature of Job's syndrome. 
      Hyperimmunoglobulinemia E syndrome should be suspected in any case of recurrent 
      giant chalazia, regardless of the patient's age. Measurement of serum IgE and 
      eosinophils, along with internal evaluation, is essential to establish a proper 
      diagnosis.
FAU - Patteri, Pierpaolo
AU  - Patteri P
AD  - Department of Ophthalmology, San Francesco Hospital, Nuoro, Italy.
FAU - Serru, Alain
AU  - Serru A
FAU - Chessa, Maria Letizia
AU  - Chessa ML
FAU - Loi, Michele
AU  - Loi M
FAU - Pinna, Antonio
AU  - Pinna A
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20080605
PL  - Netherlands
TA  - Int Ophthalmol
JT  - International ophthalmology
JID - 7904294
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Glucocorticoids)
RN  - 0 (Ointments)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - N12000U13O (Doxycycline)
RN  - VZ8RRZ51VK (Tobramycin)
SB  - IM
MH  - Administration, Oral
MH  - Anti-Bacterial Agents/administration & dosage
MH  - Chalazion/*complications/drug therapy/*pathology/surgery
MH  - Curettage
MH  - Dexamethasone/administration & dosage
MH  - Doxycycline/administration & dosage
MH  - Drug Therapy, Combination
MH  - Glucocorticoids/administration & dosage
MH  - Humans
MH  - Job Syndrome/*complications
MH  - Male
MH  - Middle Aged
MH  - Ointments
MH  - Postoperative Care
MH  - Recurrence
MH  - Tobramycin/administration & dosage
EDAT- 2008/06/06 09:00
MHDA- 2010/01/06 06:00
CRDT- 2008/06/06 09:00
PHST- 2008/01/29 00:00 [received]
PHST- 2008/05/19 00:00 [accepted]
PHST- 2008/06/06 09:00 [pubmed]
PHST- 2010/01/06 06:00 [medline]
PHST- 2008/06/06 09:00 [entrez]
AID - 10.1007/s10792-008-9238-y [doi]
PST - ppublish
SO  - Int Ophthalmol. 2009 Oct;29(5):415-7. doi: 10.1007/s10792-008-9238-y. Epub 2008 
      Jun 5.