PMID- 1853306
OWN - NLM
STAT- MEDLINE
DCOM- 19910821
LR  - 20190727
IS  - 0049-3848 (Print)
IS  - 0049-3848 (Linking)
VI  - 62
IP  - 1-2
DP  - 1991 Apr
TI  - Impaired fibrinolysis and postoperative thromboembolism in orthopedic patients.
PG  - 55-64
AB  - The incidence of deep vein thrombosis (DVT) and pulmonary embolism was studied 
      prospectively in patients undergoing elective total hip replacement. 96 patients 
      were randomly allocated to receive either low molecular weight heparin (LMWH) or 
      unfractionated heparin (UFH). All patients had bilateral phlebography and 
      pulmonary perfusion/ventilation scintigraphy 10-12 days after surgery. The 
      following fibrinolytic variables were analysed in plasma and related to 
      thromboembolism: tissue plasminogen activator (t-PA) activity, t-PA antigen (t-PA 
      Ag), plasminogen activator inhibitor (PAI-1) activity and PAI-1 antigen (PAI-1 
      Ag). No significant difference was found, regarding the fibrinolytic response to 
      surgery, between patients treated with LMWH and UFH. The level of PAI-1 activity 
      was significantly increased before operation in patients developing DVT as 
      compared to non-DVT patients (p less than 0.03). Immediately after surgery and in 
      the morning the first postoperative day the levels of PAI-1 activity, PAI-1 Ag 
      and t-PA Ag were positively correlated to thromboembolism. PAI-1 activity was the 
      only preoperative fibrinolytic variable correlated to thromboembolism.
FAU - Eriksson, B I
AU  - Eriksson BI
AD  - Institution of Orthopedics, Gothenburg University, Ostra Sjukhuset, Sweden.
FAU - Eriksson, E
AU  - Eriksson E
FAU - Risberg, B
AU  - Risberg B
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
SB  - IM
MH  - Aged
MH  - Female
MH  - Fibrinolysis/*physiology
MH  - *Hip Prosthesis
MH  - Humans
MH  - Male
MH  - Postoperative Complications/*blood/epidemiology
MH  - Prospective Studies
MH  - Thromboembolism/*blood/epidemiology
EDAT- 1991/04/01 00:00
MHDA- 1991/04/01 00:01
CRDT- 1991/04/01 00:00
PHST- 1991/04/01 00:00 [pubmed]
PHST- 1991/04/01 00:01 [medline]
PHST- 1991/04/01 00:00 [entrez]
AID - 0049-3848(91)90668-M [pii]
AID - 10.1016/0049-3848(91)90668-m [doi]
PST - ppublish
SO  - Thromb Res. 1991 Apr;62(1-2):55-64. doi: 10.1016/0049-3848(91)90668-m.