PMID- 18533557
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20080606
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 22
IP  - 6
DP  - 2008 Mar
TI  - [Expression and distribution of monocyte chemotactic protein-3 and its 
      significance in laryngeal carcinoma].
PG  - 244-7
AB  - OBJECTIVE: To investigate monocyte chemotactic protein-3 (MCP-3) mRNA and protein 
      expression and distribution in laryngeal squamous cell carcinoma (LSCC) tissue, 
      so as to study its function in the tumor development. METHOD: Immunohistochemical 
      staining and RT-PCR, and western blot were performed to detect the LSCC tissue 
      and the normal tissue adjacent tumor. RESULT: The expression of MCP-3 mRNA and 
      protein were found in the LSCC tissue and the normal tissue adjacent tumor. The 
      expression of MCP-3 mRNA and protein in LSCC tissue is much higher than that in 
      normal tissue adjacent tumor (P<0.05). There is a significant difference between 
      I-II stage III-IV stage (P<0.05). Immunohistochemical staining: positive staining 
      of MCP-3 was yellow and mainly detected in the tumor cell cytoplasm and also in 
      some normal glandular epitheliums. CONCLUSION: MCP-3 might be involved in the 
      mechanism of the tumor development, its function of chemotaxis and activation of 
      the tumor-associated macrophages would be highlighted, so that the inflammatory 
      microenvironment might play an important role in the development of tumor.
FAU - Li, Lin
AU  - Li L
AD  - Department of Otolaryngology Head and Neck Surgery, China-Japan Friendship 
      Hospital, Jilin University, Jilin, 130033, China.
FAU - Zhu, Dongdong
AU  - Zhu D
FAU - Dong, Zhen
AU  - Dong Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (CCL7 protein, human)
RN  - 0 (Chemokine CCL7)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Chemokine CCL7/*metabolism
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - RNA, Messenger/genetics
EDAT- 2008/06/07 09:00
MHDA- 2011/06/17 06:00
CRDT- 2008/06/07 09:00
PHST- 2008/06/07 09:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
PHST- 2008/06/07 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Mar;22(6):244-7.