PMID- 18534908
OWN - NLM
STAT- MEDLINE
DCOM- 20080902
LR  - 20211203
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 29
IP  - 7
DP  - 2008 Jul
TI  - Turning NF-kappaB and IRFs on and off in DC.
PG  - 329-36
LID - 10.1016/j.it.2008.03.005 [doi]
AB  - Dendritic cells (DCs) produce an array of cytokines after detecting various 
      immune adjuvants through pattern recognition receptors (PRRs). PRR signaling 
      leads to activation of transcription factors such as NF-kappaB or interferon 
      regulatory factors (IRFs) but after activation must be attenuated to avoid 
      immunopathology and to maintain tissue homeostasis. IkappaB kinase family 
      members, originally identified as classical NF-kappaB activators, are now found 
      to be broadly and crucially involved in PRR signaling in a member-specific 
      manner. Furthermore, a new mechanism for NF-kappaB downregulation is emerging 
      that involves the degradation of active NF-kappaB by the nuclear 
      ubiquitin-proteasome system. Here we review new aspects of NF-kappaB and IRF 
      regulation chiefly in DCs.
FAU - Kaisho, Tsuneyasu
AU  - Kaisho T
AD  - Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, 
      Yokohama city, Kanagawa 230-0045, Japan. tkaisho@rcai.riken.jp
FAU - Tanaka, Takashi
AU  - Tanaka T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080603
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
RN  - 0 (Interferon Regulatory Factor-3)
RN  - 0 (Interferon Regulatory Factor-7)
RN  - 0 (Interferon Type I)
RN  - 0 (NF-kappa B)
RN  - 0 (TLR7 protein, human)
RN  - 0 (TLR9 protein, human)
RN  - 0 (Toll-Like Receptor 7)
RN  - 0 (Toll-Like Receptor 9)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (TBK1 protein, human)
RN  - EC 2.7.11.10 (I-kappa B Kinase)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Homeostasis
MH  - Humans
MH  - I-kappa B Kinase/physiology
MH  - Interferon Regulatory Factor-3/*physiology
MH  - Interferon Regulatory Factor-7/*physiology
MH  - Interferon Type I/biosynthesis
MH  - NF-kappa B/*physiology
MH  - Protein Serine-Threonine Kinases/physiology
MH  - Toll-Like Receptor 7/physiology
MH  - Toll-Like Receptor 9/physiology
RF  - 77
EDAT- 2008/06/07 09:00
MHDA- 2008/09/03 09:00
CRDT- 2008/06/07 09:00
PHST- 2008/02/07 00:00 [received]
PHST- 2008/03/25 00:00 [revised]
PHST- 2008/03/25 00:00 [accepted]
PHST- 2008/06/07 09:00 [pubmed]
PHST- 2008/09/03 09:00 [medline]
PHST- 2008/06/07 09:00 [entrez]
AID - S1471-4906(08)00133-6 [pii]
AID - 10.1016/j.it.2008.03.005 [doi]
PST - ppublish
SO  - Trends Immunol. 2008 Jul;29(7):329-36. doi: 10.1016/j.it.2008.03.005. Epub 2008 
      Jun 3.