PMID- 18536597
OWN - NLM
STAT- MEDLINE
DCOM- 20080724
LR  - 20220317
IS  - 0275-004X (Print)
IS  - 0275-004X (Linking)
VI  - 28
IP  - 6
DP  - 2008 Jun
TI  - Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous 
      of patients with proliferative diabetic retinopathy and eales' disease.
PG  - 817-24
LID - 10.1097/IAE.0b013e31816576d5 [doi]
AB  - PURPOSE: To investigate the mechanism of angiogenesis in proliferative diabetic 
      retinopathy (PDR) and Eales' disease (ED) on the basis of the levels of 
      proinflammatory cytokines, angiogenic growth factor, and antiangiogenic factor in 
      the vitreous humor. METHODS: Twenty-five patients with PDR, 10 patients with ED, 
      and 25 with macular hole (MH) as control subjects were studied. The concentration 
      of the proinflammatory cytokines interleukin-6 (IL-6), IL-8, IL-1 beta; 
      chemokine-monocyte chemoattractant protein-1 (MCP-1); angiogenic factor-vascular 
      endothelial growth factor (VEGF); and antiangiogenic factor-pigment epithelium 
      derived factor (PEDF) in the vitreous fluid obtained from the eyes during 
      vitrectomy were measured by sandwich enzyme linked immunosorbent assay (ELISA). 
      RESULTS: IL-6, IL-8, MCP-1, and VEGF levels in the vitreous were significantly 
      higher in PDR (P < 0.0001) and ED (P < 0.0001) than in MH patients. Conversely, 
      the vitreous level of PEDF was significantly reduced in PDR (P < 0.0001) but not 
      in ED. A significant correlation was observed between VEGF and IL-6 in ED 
      patients. CONCLUSION: The authors demonstrate the importance of VEGF in retinal 
      neovascularization of ED which is an idiopathic inflammatory venous occlusion. 
      Further study is required to understand the interrelationship between VEGF and 
      inflammatory cytokines in PDR and ED.
FAU - Murugeswari, Ponnalagu
AU  - Murugeswari P
AD  - Department of Immunology, Dr. G. Venkataswamy Eye Research Institute, Aravind 
      Medical Research Foundation, Tamilnadu, India.
FAU - Shukla, Dhananjay
AU  - Shukla D
FAU - Rajendran, Anand
AU  - Rajendran A
FAU - Kim, Ramasamy
AU  - Kim R
FAU - Namperumalsamy, Perumalsamy
AU  - Namperumalsamy P
FAU - Muthukkaruppan, Veerappan
AU  - Muthukkaruppan V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
RN  - 0 (Cytokines)
RN  - 0 (Eye Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Serpins)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (pigment epithelium-derived factor)
SB  - IM
CIN - Retina. 2009 Jan;29(1):121-3; author reply 123. PMID: 18936719
MH  - Cytokines/*metabolism
MH  - Diabetic Retinopathy/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Eye Proteins/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factors/*metabolism
MH  - Retinal Neovascularization/metabolism
MH  - Retinal Perforations/metabolism
MH  - Retinal Vasculitis/*metabolism
MH  - Serpins/*metabolism
MH  - Vascular Endothelial Growth Factor A/*metabolism
MH  - Vitrectomy
MH  - Vitreous Body/*metabolism
EDAT- 2008/06/10 09:00
MHDA- 2008/07/25 09:00
CRDT- 2008/06/10 09:00
PHST- 2008/06/10 09:00 [pubmed]
PHST- 2008/07/25 09:00 [medline]
PHST- 2008/06/10 09:00 [entrez]
AID - 10.1097/IAE.0b013e31816576d5 [doi]
PST - ppublish
SO  - Retina. 2008 Jun;28(6):817-24. doi: 10.1097/IAE.0b013e31816576d5.