PMID- 18537462
OWN - NLM
STAT- MEDLINE
DCOM- 20081104
LR  - 20220410
IS  - 1557-8534 (Electronic)
IS  - 1547-3287 (Linking)
VI  - 17
IP  - 4
DP  - 2008 Aug
TI  - Successful acceptance of adult liver allografts by intra-bone marrow-bone marrow 
      transplantation.
PG  - 629-39
LID - 10.1089/scd.2007.0218 [doi]
AB  - Previously, we have shown that liver allografts obtained from the fetus or young 
      mice are accepted when bone marrow cells (BMCs) from adult mice of the same 
      strain are co-grafted. However, for practical clinical use, it is more convenient 
      to obtain both BMCs and liver from the same adult donors. C57BL/6 mice were 
      irradiated with a single high-dose irradiation or two low-dose irradiations and 
      injected with donor BALB/c (8 weeks old) BMCs intravenously (IV-BMT) or directly 
      into the recipient BM cavity (IBM-BMT). Liver tissues taken from the same donor 
      were, on the same day, engrafted under the kidney capsules. Higher survival rates 
      and more complete reconstitution of donor cells were achieved in the IBM-BMT 
      group than in the IV-BMT group, and this was the case in both irradiation 
      protocols. The acceptance of donor liver tissue was seen in all mice in which 
      hematolymphoid cells were replaced by donor-type cells. The liver grafts of the 
      reconstituted mice showed normal morphology and stained positively with 
      anti-albumin antibody and Periodic Acid Schiff (PAs) staining, indicating that 
      the grafted livers were accepted, had grown, and were functioning. These results 
      demonstrate that the acceptance of allogeneic liver can be achieved by cografting 
      donor BMCs via the IBM route.
FAU - Okazaki, Satoshi
AU  - Okazaki S
AD  - 1st Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, 
      Japan.
FAU - Hisha, Hiroko
AU  - Hisha H
FAU - Mizokami, Tomomi
AU  - Mizokami T
FAU - Takaki, Takashi
AU  - Takaki T
FAU - Wang, Xiaoli
AU  - Wang X
FAU - Song, Changye
AU  - Song C
FAU - Li, Qing
AU  - Li Q
FAU - Kato, Junko
AU  - Kato J
FAU - Kamiyama, Yasuo
AU  - Kamiyama Y
FAU - Ikehara, Susumu
AU  - Ikehara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
SB  - IM
MH  - Animals
MH  - *Bone Marrow Transplantation/methods
MH  - Graft Survival/*physiology
MH  - Liver/cytology/*metabolism
MH  - *Liver Transplantation/methods
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Transplantation, Homologous
EDAT- 2008/06/10 09:00
MHDA- 2008/11/05 09:00
CRDT- 2008/06/10 09:00
PHST- 2008/06/10 09:00 [pubmed]
PHST- 2008/11/05 09:00 [medline]
PHST- 2008/06/10 09:00 [entrez]
AID - 10.1089/scd.2007.0218 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2008 Aug;17(4):629-39. doi: 10.1089/scd.2007.0218.