PMID- 18537816
OWN - NLM
STAT- MEDLINE
DCOM- 20090202
LR  - 20221207
IS  - 1600-0625 (Electronic)
IS  - 0906-6705 (Linking)
VI  - 17
IP  - 12
DP  - 2008 Dec
TI  - The susceptibility to vitiligo is associated with NF-E2-related factor2 (Nrf2) 
      gene polymorphisms: a study on Chinese Han population.
PG  - 1059-62
LID - 10.1111/j.1600-0625.2008.00752.x [doi]
AB  - Vitiligo is an acquired pigmentary disorder and its pathogenesis remains unclear. 
      Oxidative stress is considered to be the initial pathogenic event in the 
      melanocyte destruction. NF-E2-related factor2 (Nrf2) is a transcription factor 
      regulating the expression of detoxifying and antioxidant genes. To investigate 
      the association of the Nrf2 gene promoter polymorphisms with vitiligo in Chinese 
      Han population, the genotypes of -686A/G, -684G/A and -650C/A and the genotyping 
      of variable number of tandem repeat were detected. The data were analysed by the 
      chi-square test and the risk was evaluated by calculating OR and 95% CI. There 
      was statistically significant difference in genotypic and allelic frequencies of 
      -650C/A between the two groups (P < 0.05). A(-650) allele was significantly 
      associated with the risk for vitiligo (OR = 1.724, chi(2) = 18.096). Polymorphism 
      of the Nrf2 gene promoter at -650C/A was associated with the development of 
      vitiligo and A(-650) allele may be one of the risk factors.
FAU - Guan, Cui-Ping
AU  - Guan CP
FAU - Zhou, Miao-Ni
AU  - Zhou MN
FAU - Xu, Ai-E
AU  - Xu AE
FAU - Kang, Ke-Fei
AU  - Kang KF
FAU - Liu, Ji-Feng
AU  - Liu JF
FAU - Wei, Xiao-Dong
AU  - Wei XD
FAU - Li, Yong-Wei
AU  - Li YW
FAU - Zhao, De-Kuang
AU  - Zhao DK
FAU - Hong, Wei-Song
AU  - Hong WS
LA  - eng
PT  - Letter
DEP - 20080604
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NFE2L2 protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Asian People
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - NF-E2-Related Factor 2/*genetics
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Sex Factors
MH  - Tandem Repeat Sequences/genetics
MH  - Vitiligo/*genetics/pathology
MH  - Young Adult
EDAT- 2008/06/10 09:00
MHDA- 2009/02/03 09:00
CRDT- 2008/06/10 09:00
PHST- 2008/06/10 09:00 [pubmed]
PHST- 2009/02/03 09:00 [medline]
PHST- 2008/06/10 09:00 [entrez]
AID - EXD752 [pii]
AID - 10.1111/j.1600-0625.2008.00752.x [doi]
PST - ppublish
SO  - Exp Dermatol. 2008 Dec;17(12):1059-62. doi: 10.1111/j.1600-0625.2008.00752.x. 
      Epub 2008 Jun 4.