PMID- 18538129
OWN - NLM
STAT- MEDLINE
DCOM- 20080724
LR  - 20131121
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 372
IP  - 4
DP  - 2008 Aug 8
TI  - Hypoxia upregulates the histone demethylase JMJD1A via HIF-1.
PG  - 892-7
LID - 10.1016/j.bbrc.2008.05.150 [doi]
AB  - The histone demethylase Jumonji domain containing 1A (JMJD1A) demethylates H3K9 
      residues and thereby transactivates distinct target genes. Investigating the 
      effect of hypoxia on JMJD1A expression, we found increased JMJD1A mRNA in 
      different organs of rats exposed to normobaric hypoxia (8% O(2)). Compared to 
      adult samples, JMJD1A was increased in most tissues of human fetuses in whom 
      oxygen supply is low compared to postnatal levels. Upregulation of JMJD1A mRNA 
      and protein in cultured human cells exposed to hypoxia or iron scavengers in 
      vitro was abrogated when hypoxia-inducible factor-1 (HIF-1) signaling was blocked 
      by siRNAs. A single pivotal hypoxia responsive element (HRE) in the promoter of 
      the human JMJD1A gene was identified that mediates JMJD1A upregulation by 
      hypoxia, iron scavengers, and HIF-1. These findings demonstrate that JMJD1A can 
      be stimulated by hypoxia both in vitro and in vivo involving binding of HIF-1 to 
      a specific HRE in the JMJD1A promoter.
FAU - Wellmann, Sven
AU  - Wellmann S
AD  - Department of Neonatology, Basel University Children's Hospital Basel (UKBB), 
      P.O. Box CH-4005, Basel, Switzerland. sven.wellmann@ukbb.ch
FAU - Bettkober, Maxi
AU  - Bettkober M
FAU - Zelmer, Andrea
AU  - Zelmer A
FAU - Seeger, Karl
AU  - Seeger K
FAU - Faigle, Marion
AU  - Faigle M
FAU - Eltzschig, Holger K
AU  - Eltzschig HK
FAU - Buhrer, Christoph
AU  - Buhrer C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080604
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (RNA, Messenger)
RN  - EC 1.14.11.- (Jumonji Domain-Containing Histone Demethylases)
RN  - EC 1.14.11.- (KDM3A protein, human)
RN  - EC 1.5.- (Oxidoreductases, N-Demethylating)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Anaerobiosis/genetics
MH  - Animals
MH  - Binding Sites
MH  - Cell Line
MH  - Fetus/metabolism
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/*metabolism
MH  - Jumonji Domain-Containing Histone Demethylases
MH  - Methylation
MH  - Oxidoreductases, N-Demethylating/*genetics/metabolism
MH  - Oxygen/*metabolism
MH  - Promoter Regions, Genetic
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Tissue Distribution
MH  - Up-Regulation
EDAT- 2008/06/10 09:00
MHDA- 2008/07/25 09:00
CRDT- 2008/06/10 09:00
PHST- 2008/05/26 00:00 [received]
PHST- 2008/05/27 00:00 [accepted]
PHST- 2008/06/10 09:00 [pubmed]
PHST- 2008/07/25 09:00 [medline]
PHST- 2008/06/10 09:00 [entrez]
AID - S0006-291X(08)01078-4 [pii]
AID - 10.1016/j.bbrc.2008.05.150 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2008 Aug 8;372(4):892-7. doi: 
      10.1016/j.bbrc.2008.05.150. Epub 2008 Jun 4.