PMID- 18538590
OWN - NLM
STAT- MEDLINE
DCOM- 20080710
LR  - 20240312
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 28
IP  - 6
DP  - 2008 Jun
TI  - Human neutrophil Fcgamma receptors initiate and play specialized nonredundant 
      roles in antibody-mediated inflammatory diseases.
PG  - 833-46
LID - 10.1016/j.immuni.2008.04.013 [doi]
AB  - Inflammation mediated by antibody-antigen complexes contributes to autoimmune 
      diseases. Mice deficient in the common Fcgamma-chain are protected from 
      IgG-mediated glomerulonephritis and the reverse passive Arthus (RPA) reaction and 
      FcR-bearing macrophages, and mast cells have been assigned primary roles in these 
      processes. Here we demonstrate that neutrophil-selective transgenic expression of 
      the two uniquely human neutrophil Fc gamma receptors (FcgammaRs), FcgammaRIIA and 
      FcgammaRIIIB, in Fcgamma-chain-deficient mice restored susceptibility to 
      progressive glomerulonephritis and the cutaneous RPA reaction. FcgammaRIIIB and 
      FcgammaRIIA mediated neutrophil accumulation, whereas FcgammaRIIA alone promoted 
      organ injury. In a model of soluble immune complexes deposited within the 
      vasculature, FcgammaRIIIB was responsible for neutrophil slow rolling and 
      adhesion whereas in the cremaster RPA, induced by both vascular and tissue 
      soluble immune complexes, FcgammaRIIA predominated. Thus, human FcgammaRs on 
      neutrophils serve as molecular links between antibody and immunological disease, 
      with FcgammaRIIA promoting tissue injury and FcgammaRIIIB and FcgammaRIIA 
      displaying specialized context-dependent functions in neutrophil recruitment.
FAU - Tsuboi, Naotake
AU  - Tsuboi N
AD  - Center of Excellence in Vascular Biology, Department of Pathology, Brigham and 
      Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
FAU - Asano, Kenichi
AU  - Asano K
FAU - Lauterbach, Michael
AU  - Lauterbach M
FAU - Mayadas, Tanya N
AU  - Mayadas TN
LA  - eng
GR  - R01 HL065095-09/HL/NHLBI NIH HHS/United States
GR  - AR050800/AR/NIAMS NIH HHS/United States
GR  - R01 HL065095/HL/NHLBI NIH HHS/United States
GR  - R01 AR050800/AR/NIAMS NIH HHS/United States
GR  - R01 AR050800-04/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Antibodies)
RN  - 0 (Antigen-Antibody Complex)
RN  - 0 (Antigens, CD)
RN  - 0 (Fc gamma receptor IIA)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Animals
MH  - Antibodies/immunology
MH  - Antigen-Antibody Complex/immunology/metabolism
MH  - Antigens, CD/immunology/metabolism
MH  - Arthus Reaction/*immunology/metabolism
MH  - Cell Adhesion
MH  - Glomerulonephritis/*immunology/metabolism
MH  - Humans
MH  - Inflammation/*immunology/metabolism
MH  - Leukocyte Rolling
MH  - Mice
MH  - Mice, Transgenic
MH  - Neutrophils/*immunology/metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Receptors, IgG/*immunology/metabolism
PMC - PMC2577844
MID - NIHMS55828
EDAT- 2008/06/10 09:00
MHDA- 2008/07/11 09:00
PMCR- 2009/06/01
CRDT- 2008/06/10 09:00
PHST- 2007/07/25 00:00 [received]
PHST- 2008/02/22 00:00 [revised]
PHST- 2008/04/01 00:00 [accepted]
PHST- 2008/06/10 09:00 [pubmed]
PHST- 2008/07/11 09:00 [medline]
PHST- 2008/06/10 09:00 [entrez]
PHST- 2009/06/01 00:00 [pmc-release]
AID - S1074-7613(08)00230-6 [pii]
AID - 10.1016/j.immuni.2008.04.013 [doi]
PST - ppublish
SO  - Immunity. 2008 Jun;28(6):833-46. doi: 10.1016/j.immuni.2008.04.013.