PMID- 18538870
OWN - NLM
STAT- MEDLINE
DCOM- 20080930
LR  - 20080711
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 192
IP  - 2
DP  - 2008 Oct 10
TI  - Nature vs. nurture: can enrichment rescue the behavioural phenotype of BDNF 
      heterozygous mice?
PG  - 254-8
LID - 10.1016/j.bbr.2008.04.015 [doi]
AB  - In earlier experiments we have demonstrated that group-housing in a rather 
      impoverished "standard" environment can be a crucial stress factor in male 
      C57Bl/6 mice. The present study aimed at investigating the effect of combining a 
      probable genetic vulnerability--postulated by the "Neurotrophin Hypothesis of 
      Depression"--with the potentially modulating influence of a stressful environment 
      such as "impoverished" standard housing conditions. For that purpose mice with a 
      partial deletion of brain-derived neurotrophic factor (BDNF) were group-housed 
      under standard and enriched housing conditions and analysed in a well-established 
      test battery for emotional behaviours. Standard group-housing affected emotional 
      behaviour in male and female BDNF heterozygous mice, causing an increase in 
      anxiety, changes in exploration as well as nociception. Providing the animals' 
      cages with supplementary enrichment, however, led to a rescue of emotional 
      alterations, which emphasises the significance of external factors and their 
      relevance for a valid investigation of genetic aspects in these mutants as well 
      as others, which may be examined in terms of stress-responsiveness or 
      emotionality.
FAU - Chourbaji, Sabine
AU  - Chourbaji S
AD  - Central Institute of Mental Health Mannheim (ZI), University of Heidelberg, 
      Germany. sabine.chourbaji@zi-mannheim.de
FAU - Brandwein, Christiane
AU  - Brandwein C
FAU - Vogt, Miriam A
AU  - Vogt MA
FAU - Dormann, Christof
AU  - Dormann C
FAU - Hellweg, Rainer
AU  - Hellweg R
FAU - Gass, Peter
AU  - Gass P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080424
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Anxiety/physiopathology/psychology
MH  - Behavior, Animal/*physiology
MH  - Brain-Derived Neurotrophic Factor/deficiency/*genetics/physiology
MH  - *Environment
MH  - Exploratory Behavior/physiology
MH  - Female
MH  - Heterozygote
MH  - *Housing, Animal
MH  - Male
MH  - Maze Learning/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Motor Activity/physiology
MH  - Pain Threshold
MH  - Phenotype
MH  - Stress, Psychological/genetics/pathology/*physiopathology
EDAT- 2008/06/10 09:00
MHDA- 2008/10/01 09:00
CRDT- 2008/06/10 09:00
PHST- 2008/01/08 00:00 [received]
PHST- 2008/04/14 00:00 [revised]
PHST- 2008/04/17 00:00 [accepted]
PHST- 2008/06/10 09:00 [pubmed]
PHST- 2008/10/01 09:00 [medline]
PHST- 2008/06/10 09:00 [entrez]
AID - S0166-4328(08)00228-3 [pii]
AID - 10.1016/j.bbr.2008.04.015 [doi]
PST - ppublish
SO  - Behav Brain Res. 2008 Oct 10;192(2):254-8. doi: 10.1016/j.bbr.2008.04.015. Epub 
      2008 Apr 24.