PMID- 18540051
OWN - NLM
STAT- MEDLINE
DCOM- 20080703
LR  - 20221207
IS  - 1744-3091 (Electronic)
IS  - 1744-3091 (Linking)
VI  - 64
IP  - Pt 6
DP  - 2008 Jun 1
TI  - Structure of a SARS coronavirus-derived peptide bound to the human major 
      histocompatibility complex class I molecule HLA-B*1501.
PG  - 459-62
LID - 10.1107/S1744309108012396 [doi]
AB  - The human leukocyte antigen (HLA) class I system comprises a highly polymorphic 
      set of molecules that specifically bind and present peptides to cytotoxic T 
      cells. HLA-B*1501 is a prototypical member of the HLA-B62 supertype and only two 
      peptide-HLA-B*1501 structures have been determined. Here, the crystal structure 
      of HLA-B*1501 in complex with a SARS coronavirus-derived nonapeptide (VQQESSFVM) 
      has been determined at high resolution (1.87 A). The peptide is deeply anchored 
      in the B and F pockets, but with the Glu4 residue pointing away from the floor in 
      the peptide-binding groove, making it available for interactions with a potential 
      T-cell receptor.
FAU - Roder, Gustav
AU  - Roder G
AD  - Institute of International Health, Immunology and Microbiology, University of 
      Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark. g.roder@immi.ku.dk
FAU - Kristensen, Ole
AU  - Kristensen O
FAU - Kastrup, Jette S
AU  - Kastrup JS
FAU - Buus, Soren
AU  - Buus S
FAU - Gajhede, Michael
AU  - Gajhede M
LA  - eng
GR  - HHSN2662004-00025C/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080517
PL  - England
TA  - Acta Crystallogr Sect F Struct Biol Cryst Commun
JT  - Acta crystallographica. Section F, Structural biology and crystallization 
      communications
JID - 101226117
RN  - 0 (HLA-B Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Ligands)
RN  - 0 (Oligopeptides)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Binding Sites/immunology
MH  - Crystallography, X-Ray
MH  - HLA-B Antigens/*chemistry/genetics/immunology
MH  - Histocompatibility Antigens Class I/genetics/isolation & purification/*metabolism
MH  - Humans
MH  - Hydrogen Bonding
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Ligands
MH  - Models, Molecular
MH  - Mutagenesis, Site-Directed
MH  - Oligopeptides/chemical synthesis/chemistry/*immunology/isolation & 
      purification/*metabolism
MH  - Protein Binding/immunology
MH  - Protein Structure, Secondary
MH  - Severe acute respiratory syndrome-related coronavirus/*chemistry/immunology
MH  - Water/chemistry
PMC - PMC2496847
EDAT- 2008/06/10 09:00
MHDA- 2008/07/04 09:00
PMCR- 2009/06/01
CRDT- 2008/06/10 09:00
PHST- 2008/03/05 00:00 [received]
PHST- 2008/04/28 00:00 [accepted]
PHST- 2008/06/10 09:00 [pubmed]
PHST- 2008/07/04 09:00 [medline]
PHST- 2008/06/10 09:00 [entrez]
PHST- 2009/06/01 00:00 [pmc-release]
AID - S1744309108012396 [pii]
AID - en5298 [pii]
AID - 10.1107/S1744309108012396 [doi]
PST - ppublish
SO  - Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):459-62. 
      doi: 10.1107/S1744309108012396. Epub 2008 May 17.