PMID- 18540361
OWN - NLM
STAT- MEDLINE
DCOM- 20080729
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 66
IP  - 6
DP  - 2008 Jun
TI  - [Myasthenia gravis induced by autoantibodies against MuSK].
PG  - 1149-54
AB  - Myasthenia gravis (MG) is caused by the failure of neuromuscular transmission 
      mediated by autoantibodies. That is, the binding of autoantibodies to 
      postsynaptic membranes in neuromuscular junctions (NMJ) results in weakening of 
      the ocular, bulbar and limb muscles and produces the characteristic syndrome of 
      MG. About 80 to 85% of patients witth MG have autoantibodies against 
      acetylcholine receptors (AChR). Antibodies against muscle-specific kinase (MuSK) 
      have been found in 30% of MG patients without AChR antibodies. Here we describe 
      recent progress toward understanding the pathogenic role of MuSK antibodies in 
      the decline of muscle strength that typifies MG.
FAU - Shigemoto, Kazuhiro
AU  - Shigemoto K
AD  - Research Team for Molecular Biomarkers, Tokyo Metropolitan Institute of 
      Gerontology.
FAU - Konishi, Tetsuro
AU  - Konishi T
FAU - Ohta, Mitsuhiro
AU  - Ohta M
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, Cholinergic)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Autoantibodies/*immunology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mice
MH  - Myasthenia Gravis/*immunology
MH  - Neuromuscular Junction/immunology
MH  - Rabbits
MH  - Receptor Protein-Tyrosine Kinases/*immunology
MH  - Receptors, Cholinergic/*immunology
RF  - 19
EDAT- 2008/06/11 09:00
MHDA- 2008/07/30 09:00
CRDT- 2008/06/11 09:00
PHST- 2008/06/11 09:00 [pubmed]
PHST- 2008/07/30 09:00 [medline]
PHST- 2008/06/11 09:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 2008 Jun;66(6):1149-54.