PMID- 18540991
OWN - NLM
STAT- MEDLINE
DCOM- 20090127
LR  - 20081121
IS  - 1468-3083 (Electronic)
IS  - 0926-9959 (Linking)
VI  - 22
IP  - 11
DP  - 2008 Nov
TI  - Pathogenesis of subacute cutaneous lupus erythematosus.
PG  - 1281-9
LID - 10.1111/j.1468-3083.2008.02806.x [doi]
AB  - Subacute cutaneous lupus erythematosus (SCLE) is a photosensitive form of 
      lupus-specific skin lesion that is strongly associated with the presence of 
      anti-Ro/SSA autoantibody. The pathogenesis of SCLE includes genetic, 
      environmental and immunologic factors. Recent studies provide strong evidence for 
      the involvement of innate and cell-mediated immunity, underlying the important 
      role of plasmacytoid dendritic cells, interferon-alpha and antibody-dependent 
      cell cytotoxicity. In addition, a variety of cytokines, chemokines and adhesion 
      molecules have been found to participate in the expansion phase of the autoimmune 
      effector mechanisms. This article summarizes the recent immunological findings 
      and reviews the current mechanisms which are implied in the development of the 
      disease.
FAU - Stavropoulos, P G
AU  - Stavropoulos PG
AD  - First Department of Dermatology, School of Medicine, University of Athens, 
      Athens, Greece.
FAU - Goules, A V
AU  - Goules AV
FAU - Avgerinou, G
AU  - Avgerinou G
FAU - Katsambas, A D
AU  - Katsambas AD
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080606
PL  - England
TA  - J Eur Acad Dermatol Venereol
JT  - Journal of the European Academy of Dermatology and Venereology : JEADV
JID - 9216037
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
SB  - IM
MH  - Antibody-Dependent Cell Cytotoxicity
MH  - Cell Adhesion Molecules/physiology
MH  - Chemokines/physiology
MH  - Cytokines/physiology
MH  - Humans
MH  - Immunity, Cellular
MH  - Immunity, Innate
MH  - Lupus Erythematosus, Cutaneous/genetics/immunology/*pathology/physiopathology
RF  - 82
EDAT- 2008/06/11 09:00
MHDA- 2009/01/28 09:00
CRDT- 2008/06/11 09:00
PHST- 2008/06/11 09:00 [pubmed]
PHST- 2009/01/28 09:00 [medline]
PHST- 2008/06/11 09:00 [entrez]
AID - JDV2806 [pii]
AID - 10.1111/j.1468-3083.2008.02806.x [doi]
PST - ppublish
SO  - J Eur Acad Dermatol Venereol. 2008 Nov;22(11):1281-9. doi: 
      10.1111/j.1468-3083.2008.02806.x. Epub 2008 Jun 6.