PMID- 18541952
OWN - NLM
STAT- MEDLINE
DCOM- 20080620
LR  - 20191210
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Linking)
VI  - 44
IP  - 5
DP  - 2008
TI  - [Evaluation of a chronic fatigue in patients with moderate-to-severe chronic 
      heart failure].
PG  - 366-72
AB  - THE AIM OF THE STUDY: To evaluate the chronic fatigue and its relation to the 
      function of hypothalamus-pituitary-adrenal axis in patients with New York Heart 
      Association (NYHA) functional class III-IV chronic heart failure. MATERIAL AND 
      METHODS: A total of 170 patients with NYHA functional class III-IV chronic heart 
      failure completed MFI-20L, DUFS, and DEFS questionnaires assessing chronic 
      fatigue and underwent echocardiography. Blood cortisol concentration was assessed 
      at 8:00 am and 3:00 pm, and plasma N-terminal brain natriuretic pro-peptide 
      (NT-proBNP) concentration was measured at 8:00 am. Neurohumoral investigations 
      were repeated before cardiopulmonary exercise test and after it. RESULTS: The 
      results of all questionnaires showed that 100% of patients with NYHA functional 
      class III-IV heart failure complained of chronic fatigue. The level of overall 
      fatigue was 54.5+/-31.5 points; physical fatigue - 56.8+/-24.6 points. Blood 
      cortisol concentration at 8:00 am was normal (410.1+/-175.1 mmol/L) in majority 
      of patients. Decreased concentration was only in four patients (122.4+/-15.5 
      mmol/L); one of these patients underwent heart transplantation. In the afternoon, 
      blood cortisol concentration was insufficiently decreased (355.6+/-160.3 mmol/L); 
      reaction to a physical stress was attenuated (Delta 92.9 mmol/L). Plasma 
      NT-proBNP concentration was 2188.9+/-1852.2 pg/L; reaction to a physical stress 
      was diminished (Delta 490.3 pg/L). CONCLUSION: All patients with NYHA class 
      III-IV heart failure complained of daily chronic fatigue. Insufficiently 
      decreased blood cortisol concentration in the afternoon showed that in the 
      presence of chronic fatigue in long-term cardiovascular organic disease, disorder 
      of a hypothalamus-pituitary-adrenal axis is involved.
FAU - Jasiukeviciene, Lina
AU  - Jasiukeviciene L
AD  - Institute of Cardiology, Kaunas University of Medicine, Lithuania. 
      lina.jas@med.kmu.lt
FAU - Vasiliauskas, Donatas
AU  - Vasiliauskas D
FAU - Kavoliuniene, Ausra
AU  - Kavoliuniene A
FAU - Marcinkeviciene, Jolanta
AU  - Marcinkeviciene J
FAU - Grybauskiene, Regina
AU  - Grybauskiene R
FAU - Grizas, Vytautas
AU  - Grizas V
FAU - Tumyniene, Vida
AU  - Tumyniene V
LA  - lit
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
TT  - Serganciuju vidutinio sunkumo ir sunkiu letiniu sirdies nepakankamumu letinio 
      nuovargio tyrimas.
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Echocardiography
MH  - Fatigue Syndrome, Chronic/blood/*diagnosis/*etiology
MH  - Heart Failure/blood/*complications/diagnosis/*physiopathology
MH  - Heart Transplantation
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Hypothalamo-Hypophyseal System/physiopathology
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Oxygen Consumption
MH  - Peptide Fragments/blood
MH  - Physical Exertion
MH  - Pituitary-Adrenal System/physiopathology
MH  - Stroke Volume
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Ventricular Function, Left
EDAT- 2008/06/11 09:00
MHDA- 2008/06/21 09:00
CRDT- 2008/06/11 09:00
PHST- 2008/06/11 09:00 [pubmed]
PHST- 2008/06/21 09:00 [medline]
PHST- 2008/06/11 09:00 [entrez]
AID - 0805-04l [pii]
PST - ppublish
SO  - Medicina (Kaunas). 2008;44(5):366-72.