PMID- 18541955
OWN - NLM
STAT- MEDLINE
DCOM- 20080620
LR  - 20221207
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Linking)
VI  - 44
IP  - 5
DP  - 2008
TI  - Matrix metalloproteinase-3 gene polymorphism and dilatative pathology of 
      ascending thoracic aorta.
PG  - 386-91
AB  - Matrix metalloproteinase-3 (MMP-3) degrades extracellular matrix and may lead to 
      development of dilatative pathology of ascending thoracic aorta. Expression of 
      MMP-3 depends upon the 5A/6A polymorphism in the promoter region. An increased 
      number of 5A alleles leads to high expression of MMP-3. Thus, objective of the 
      study was to determine whether the 5A/6A polymorphism in the promoter region of 
      MMP-3 gene is associated with the development of dilatative pathology of 
      ascending thoracic aorta. We studied 76 patients (age ranged from 31 to 81 years; 
      median age, 64 years) who underwent aortic reconstruction surgery due to 
      dilatative pathology of ascending thoracic aorta and a random sample of the 
      population (n=604) aged 25-64 years, all from Lithuania. DNA was analyzed by 
      using real-time polymerase chain reaction to genotype polymorphism 5A/6A at a 
      position -1171 of the MMP3 gene promoter. The prevalence of MMP-3 genotypes was 
      similar in the group of dilatative pathology of ascending thoracic aorta and 
      random sample of population. The frequency of 5A allele did not differ 
      significantly between both groups and was 0.506 and 0.514, respectively. Male 
      carriers of 5A/5A genotype were significantly younger compared with those with 
      the 6A/6A genotype. In conclusion, the frequency of MMP-3 promoter 5A/6A 
      genotypes did not differ between the group of patients with dilatative pathology 
      of ascending thoracic aorta and the random sample of population, but the males 
      with dilatative pathology of ascending thoracic aorta and 5A/5A genotype required 
      aortic reconstruction surgery at the younger age than the males carrying 6A/6A 
      genotype in the MMP-3 promoter region.
FAU - Lesauskaite, Vaiva
AU  - Lesauskaite V
AD  - Institute of Cardiology, Kaunas University of Medicine, Lithuania. 
      vaiva.lesauskaite@med.kmu.lt
FAU - Sinkunaite, Giedre
AU  - Sinkunaite G
FAU - Benetis, Rimantas
AU  - Benetis R
FAU - Grabauskas, Vilius
AU  - Grabauskas V
FAU - Vaskelyte, Jolanta
AU  - Vaskelyte J
FAU - Smalinskiene, Alina
AU  - Smalinskiene A
FAU - Simonyte, Sandrita
AU  - Simonyte S
FAU - Jariene, Giedre
AU  - Jariene G
FAU - Tatarunas, Vacis
AU  - Tatarunas V
FAU - Klumbiene, Jurate
AU  - Klumbiene J
FAU - Petkeviciene, Janina
AU  - Petkeviciene J
FAU - Kinduris, Sarunas
AU  - Kinduris S
FAU - Giedraitis, Saulius
AU  - Giedraitis S
FAU - Sakalauskas, Juozas
AU  - Sakalauskas J
FAU - Bolys, Ramunas
AU  - Bolys R
FAU - Sirvinskas, Edmundas
AU  - Sirvinskas E
FAU - Lenkutis, Tadas
AU  - Lenkutis T
FAU - Pangonyte, Dalia
AU  - Pangonyte D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 9007-49-2 (DNA)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Aortic Dissection/*genetics/pathology/surgery
MH  - Aorta, Thoracic/*pathology
MH  - Aortic Aneurysm, Thoracic/*genetics/pathology/surgery
MH  - DNA/isolation & purification
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sex Factors
MH  - Statistics, Nonparametric
EDAT- 2008/06/11 09:00
MHDA- 2008/06/21 09:00
CRDT- 2008/06/11 09:00
PHST- 2008/06/11 09:00 [pubmed]
PHST- 2008/06/21 09:00 [medline]
PHST- 2008/06/11 09:00 [entrez]
AID - 0805-07e [pii]
PST - ppublish
SO  - Medicina (Kaunas). 2008;44(5):386-91.