PMID- 18542080
OWN - NLM
STAT- MEDLINE
DCOM- 20080625
LR  - 20080618
IS  - 1471-0064 (Electronic)
IS  - 1471-0056 (Linking)
VI  - 9
IP  - 7
DP  - 2008 Jul
TI  - The genetics of multiple sclerosis: SNPs to pathways to pathogenesis.
PG  - 516-26
LID - 10.1038/nrg2395 [doi]
AB  - Multiple sclerosis (MS) is an autoimmune demyelinating disease and a common cause 
      of neurological disability in young adults. The modest heritability of MS 
      reflects complex genetic effects and multifaceted gene-environment interactions. 
      The human leukocyte antigen (HLA) region is the strongest susceptibility locus 
      for MS, but a genome-wide association study recently identified new 
      susceptibility genes. Progress in high-throughput genotyping and sequencing 
      technologies and a better understanding of the structural organization of the 
      human genome, together with powerful brain-imaging techniques that refine the 
      phenotype, suggest that the tools could finally exist to identify the full set of 
      genes influencing the pathogenesis of MS.
FAU - Oksenberg, Jorge R
AU  - Oksenberg JR
AD  - Department of Neurology, School of Medicine, University of California at San 
      Francisco, 513 Parnassus Avenue, San Francisco, California 94143-0435, USA. 
      jorge.oksenberg@ucsf.edu
FAU - Baranzini, Sergio E
AU  - Baranzini SE
FAU - Sawcer, Stephen
AU  - Sawcer S
FAU - Hauser, Stephen L
AU  - Hauser SL
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080610
PL  - England
TA  - Nat Rev Genet
JT  - Nature reviews. Genetics
JID - 100962779
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Animals
MH  - *Genetic Predisposition to Disease
MH  - Genome, Human
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Multiple Sclerosis/*genetics
MH  - *Polymorphism, Single Nucleotide
RF  - 125
EDAT- 2008/06/11 09:00
MHDA- 2008/06/26 09:00
CRDT- 2008/06/11 09:00
PHST- 2008/06/11 09:00 [pubmed]
PHST- 2008/06/26 09:00 [medline]
PHST- 2008/06/11 09:00 [entrez]
AID - nrg2395 [pii]
AID - 10.1038/nrg2395 [doi]
PST - ppublish
SO  - Nat Rev Genet. 2008 Jul;9(7):516-26. doi: 10.1038/nrg2395. Epub 2008 Jun 10.