PMID- 18542427
OWN - NLM
STAT- MEDLINE
DCOM- 20080821
LR  - 20190516
IS  - 1094-4087 (Electronic)
IS  - 1094-4087 (Linking)
VI  - 16
IP  - 5
DP  - 2008 Mar 3
TI  - Spectroscopic intravascular photoacoustic imaging to differentiate 
      atherosclerotic plaques.
PG  - 3362-7
AB  - The potential of intravascular photoacoustic (IVPA) imaging to detect 
      atherosclerosis was previously demonstrated using a 532 nm nanosecond pulsed 
      laser and an intravascular ultrasound (IVUS) imaging catheter. However, to 
      differentiate vulnerable plaques, the composition of plaques needs to be imaged. 
      Therefore, we introduce a multi-wavelength photoacoustic imaging method to 
      distinguish various types of plaques. Multi-spectral IVPA imaging of ex vivo 
      samples of normal and atherosclerotic rabbit aorta was performed at several 
      wavelengths within 680-900 nm range. The spectral variation of photoacoustic 
      response was extracted and a spectroscopic analysis was performed. The results of 
      our preliminary study suggest that the spectroscopic intravascular photoacoustic 
      imaging technique can be used to differentiate fibrous and lipid components of 
      the atherosclerotic plaques.
FAU - Sethuraman, Shriram
AU  - Sethuraman S
AD  - Department of Biomedical Engineering, The University of Texas at Austin, 1 
      University Station C0800, Austin, TX 78712 USA.
FAU - Amirian, James H
AU  - Amirian JH
FAU - Litovsky, Silvio H
AU  - Litovsky SH
FAU - Smalling, Richard W
AU  - Smalling RW
FAU - Emelianov, Stanislav Y
AU  - Emelianov SY
LA  - eng
GR  - EB004963/EB/NIBIB NIH HHS/United States
GR  - HL084076/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Opt Express
JT  - Optics express
JID - 101137103
SB  - IM
MH  - Animals
MH  - Atherosclerosis/*classification/*diagnosis
MH  - Diagnosis, Differential
MH  - Elasticity Imaging Techniques/*methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - In Vitro Techniques
MH  - Rabbits
MH  - Spectrum Analysis/*methods
EDAT- 2008/06/11 09:00
MHDA- 2008/08/22 09:00
CRDT- 2008/06/11 09:00
PHST- 2008/06/11 09:00 [pubmed]
PHST- 2008/08/22 09:00 [medline]
PHST- 2008/06/11 09:00 [entrez]
AID - 154707 [pii]
AID - 10.1364/oe.16.003362 [doi]
PST - ppublish
SO  - Opt Express. 2008 Mar 3;16(5):3362-7. doi: 10.1364/oe.16.003362.