PMID- 18543122
OWN - NLM
STAT- MEDLINE
DCOM- 20090427
LR  - 20211020
IS  - 1559-1174 (Electronic)
IS  - 1535-1084 (Linking)
VI  - 10
IP  - 4
DP  - 2008
TI  - Association study of theta EEG asymmetry and brain-derived neurotrophic factor 
      gene variants in childhood-onset mood disorder.
PG  - 343-55
LID - 10.1007/s12017-008-8038-x [doi]
AB  - BACKGROUND: Childhood-onset mood disorders (COMD) include various serious, 
      disabling psychiatric conditions that are heterogeneous in presentation and 
      etiology. Because intermediate phenotypes may help to identify genetic 
      contributors to COMD, we tested for an association between variants in the 
      brain-derived neurotrophic factor (BDNF) gene and theta EEG asymmetry, both of 
      which have been independently implicated in affective disorders. METHODS: Theta 
      EEG asymmetry measures were calculated for a total of 191 individuals with COMD 
      and 93 controls, who were also genotyped at seven BDNF single-nucleotide 
      polymorphism (SNPs), two intergenic flanking SNPs, and one SNP in the lin-7 
      homolog C (Caenorhabditis elegans) (LIN7C) gene. RESULTS: Adjusting for sex and 
      ethnicity in linear models of asymmetry scores at ten brain regions, significant 
      genotype and genotype-by-ethnicity interactions were observed for marker Val66Met 
      in two parietal (P3/4 and P7/8) regions in the depressed group only. CONCLUSIONS: 
      Our results suggest that the functional Val66Met polymorphism affects theta EEG 
      asymmetry in parietal brain regions specifically in individuals with COMD.
FAU - Bulgin, Natalie L
AU  - Bulgin NL
AD  - Centre for Addiction and Mental Health, University of Toronto, 250 College St., 
      Toronto, ON, Canada.
FAU - Strauss, John S
AU  - Strauss JS
FAU - King, Nicole A
AU  - King NA
FAU - Shaikh, Sajid A
AU  - Shaikh SA
FAU - George, Charles J
AU  - George CJ
FAU - Fox, Nathan A
AU  - Fox NA
FAU - Barr, Cathy L
AU  - Barr CL
FAU - Kovacs, Maria
AU  - Kovacs M
FAU - Kennedy, James L
AU  - Kennedy JL
LA  - eng
GR  - 5P01-MH056193/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080610
PL  - United States
TA  - Neuromolecular Med
JT  - Neuromolecular medicine
JID - 101135365
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Amino Acid Substitution/genetics
MH  - Brain/metabolism/*physiopathology
MH  - Brain Mapping
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - DNA Mutational Analysis
MH  - Electroencephalography
MH  - Female
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Variation/genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Mood Disorders/*genetics/metabolism/*physiopathology
MH  - Parietal Lobe/metabolism/physiopathology
MH  - Polymorphism, Single Nucleotide/genetics
MH  - *Theta Rhythm
MH  - Young Adult
EDAT- 2008/06/11 09:00
MHDA- 2009/04/28 09:00
CRDT- 2008/06/11 09:00
PHST- 2007/12/03 00:00 [received]
PHST- 2008/05/06 00:00 [accepted]
PHST- 2008/06/11 09:00 [pubmed]
PHST- 2009/04/28 09:00 [medline]
PHST- 2008/06/11 09:00 [entrez]
AID - 10.1007/s12017-008-8038-x [doi]
PST - ppublish
SO  - Neuromolecular Med. 2008;10(4):343-55. doi: 10.1007/s12017-008-8038-x. Epub 2008 
      Jun 10.