PMID- 18543486
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20161124
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 28
IP  - 4
DP  - 2008 Apr
TI  - [Effect of zedoary turmeric oil-eluting stents for post-stenting restenosis 
      prevention and treatment].
PG  - 326-9
AB  - OBJECTIVE: To investigate the effect and safety of Zedoary Turmeric Oil 
      (ZTO)-eluting stents for post-coronary stenting restenosis prevention and 
      treatment in the experimental dogs. METHODS: Bare stents, stents coated with 
      polybutyl methacrylate/Nano silica, and stents eluted with 100 microg ZTO were 
      randomly deployed in canine anterior descending or circumflex coronary artery. 
      Four weeks after stent implantation, the dogs were sacrificed and the vascular 
      histomorphologic changes in the stenting segment analyzed. RESULTS: Thickened 
      intima could be seen under light microscope in the bare or coated stents, but 
      thinner in ZTO-duting stent, with no sub-intimal hemorrhage, medial or 
      adventitial necrosis, wall adhesive thrombus, or infiltration of inflammatory 
      cells. Scanning electric microscopy showed the intima was intact. 
      Histomorphologic analysis showed that the thickness and area of neo-intima, and 
      the lumen stenosis percent in artery stented with ZTO eluting stents were 
      significantly lower than those stented with bare or coated stents (P <0.01), and 
      thus the lumen cavity was expanded (P < 0.01), while no statistic significant 
      difference between polymer and bare stents was found (P > 0.05). CONCLUSION: 
      ZTO-eluting stent is available and safe, and it could significantly inhibit the 
      growth of neo-intimal in canine coronary mode after stenting, showing a 
      restenosis preventive and treatment effect.
FAU - Zhao, Jun-Li
AU  - Zhao JL
AD  - Department of Cardiology, The Afiliated First People's Hospital of Shanghai 
      Jiaotong University, Shanghai. jlzhao2008cn@yahoo.com.cn
FAU - Sun, Bao-Gui
AU  - Sun BG
FAU - Wen, Qin-Zhu
AU  - Wen QZ
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Plant Extracts)
RN  - 0 (Plant Oils)
RN  - 856YO1Z64F (turmeric extract)
SB  - IM
MH  - Animals
MH  - Coronary Restenosis/*drug therapy/*prevention & control
MH  - Curcuma/*chemistry
MH  - Disease Models, Animal
MH  - Dogs
MH  - Drug-Eluting Stents
MH  - Female
MH  - Humans
MH  - Male
MH  - Plant Extracts/*administration & dosage
MH  - Plant Oils/*administration & dosage
MH  - Random Allocation
EDAT- 2008/06/12 09:00
MHDA- 2010/08/11 06:00
CRDT- 2008/06/12 09:00
PHST- 2008/06/12 09:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
PHST- 2008/06/12 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Apr;28(4):326-9.