PMID- 18544228
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20131121
IS  - 1743-2928 (Electronic)
IS  - 1351-0002 (Linking)
VI  - 13
IP  - 3
DP  - 2008
TI  - Markers of oxidative damage in chronic heart failure: role in disease 
      progression.
PG  - 109-16
LID - 10.1179/135100008X259204 [doi]
AB  - BACKGROUND: We aimed to study the relationship between markers of oxidative lipid 
      or protein damage and ventricular remodeling and the validity of 
      8-epi-prostaglandin F(2alpha) (8-epi-PGF(2alpha)) as an indicator of disease 
      severity in patients with ischemic chronic heart failure (CHF). PATIENTS AND 
      METHODS: We enrolled four groups of 12 patients with varying CHF according to the 
      New York Heart Association (NYHA) classification and 25 controls. Urinary 
      8-epi-PGF(2alpha) and plasma malondialdehyde and protein thiol (P-SH) groups were 
      correlated with echocardiographic indices of remodeling. The reliability of 
      isoprostanes was analyzed by a receiver operating characteristics (ROC) curve. 
      RESULTS: NYHA class III and IV patients exhibited elevated 8-epi-PGF(2alpha) 
      levels, increased malondialdehyde concentrations and decreased P-SH groups when 
      compared to controls and NYHA I and II patients. 8-Epi-PGF(2alpha) and P-SH 
      groups correlated significantly with indices of remodeling. The ROC curve drawn 
      for 8-epi-PGF(2alpha) allowed us to differentiate NYHA class III and IV patients 
      from NYHA class I and II patients with a sensitivity of 95.8% and specificity of 
      95.8% (cut off 0.84 ng/mg creatinine; area under curve 0.99; P < 0.001). 
      CONCLUSIONS: Markers of oxidative damage are unlikely to play a significant role 
      in early stages of CHF. However, they might become important in the course of CHF 
      when their concentrations reach critical levels. Urinary 8-epi-PGF(2alpha) is a 
      reliable indicator of symptomatic CHF.
FAU - Radovanovic, Slavica
AU  - Radovanovic S
AD  - University Hospital Bezanijska Kosa, Belgrade, Serbia.
FAU - Krotin, Mirjana
AU  - Krotin M
FAU - Simic, Dragan V
AU  - Simic DV
FAU - Mimic-Oka, Jasmina
AU  - Mimic-Oka J
FAU - Savic-Radojevic, Ana
AU  - Savic-Radojevic A
FAU - Pljesa-Ercegovac, Marija
AU  - Pljesa-Ercegovac M
FAU - Matic, Marija
AU  - Matic M
FAU - Ninkovic, Nebojsa
AU  - Ninkovic N
FAU - Ivanovic, Branislava
AU  - Ivanovic B
FAU - Simic, Tatjana
AU  - Simic T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Redox Rep
JT  - Redox report : communications in free radical research
JID - 9511366
RN  - 0 (Isoprostanes)
RN  - 0 (Lipids)
RN  - 27415-26-5 (8-epi-prostaglandin F2alpha)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - B7IN85G1HY (Dinoprost)
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - Dinoprost/analogs & derivatives/urine
MH  - *Disease Progression
MH  - Echocardiography/methods
MH  - Female
MH  - Heart Failure/metabolism/*pathology
MH  - Humans
MH  - Isoprostanes/chemistry
MH  - Lipids/chemistry
MH  - Male
MH  - Malondialdehyde/blood/chemistry
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Ventricular Remodeling
EDAT- 2008/06/12 09:00
MHDA- 2008/08/08 09:00
CRDT- 2008/06/12 09:00
PHST- 2008/06/12 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2008/06/12 09:00 [entrez]
AID - 10.1179/135100008X259204 [doi]
PST - ppublish
SO  - Redox Rep. 2008;13(3):109-16. doi: 10.1179/135100008X259204.