PMID- 18544281
OWN - NLM
STAT- MEDLINE
DCOM- 20080806
LR  - 20191110
IS  - 1488-2353 (Electronic)
IS  - 0147-958X (Linking)
VI  - 31
IP  - 3
DP  - 2008
TI  - Phaeochromocytoma combined with subclinical Cushing's syndrome and pituitary 
      microadenoma.
PG  - E176-81
AB  - OBJECTIVES: Phaeochromocytoma (PHEO) occasionally associates with pathological 
      lesions of the adrenal cortex. The coexistence of PHEO and pre-clinical Cushing's 
      syndrome (PCS) of the same adrenal gland has rarely been reported. We report a 
      case of PHEO and PCS originating from the same adrenal gland and discuss the 
      peculiar diagnostic aspects of this entity. CLINICAL PRESENTATION: A 64 yr old 
      man was hospitalized to evaluate the right adrenal mass which was discovered 
      incidentally by ultrasonography. He had a history of type 2 diabetes mellitus and 
      hyperlipidemia. Blood pressure measurements were all normal during his hospital 
      stay. Laboratory examination showed: urinary catecholamines were markedly 
      increased. HbA1C of 14.3 %, midnight cortisol of 11(microg/dL), cortisol was not 
      suppressed after the overnight 1 mg oral dexamethasone suppression test (DST): 
      3.42(microg/dL), 24 hr free cortisol in the urine : 213 microg/day (10-100), 
      cortisol levels were suppressed more than 50% with 8 mg of dexamethasone. CT scan 
      of the adrenal glands showed a 6 cm well encapsulated right adrenal mass together 
      with a clearly normal left adrenal gland. MRI investigation of the sella turcica 
      revealed a pituitary microadenoma on the right side of the adenohypophysis He was 
      treated with alpha and subsequent beta blockers after the diagnosis of PHEO and 
      PCS was made. Right adrenalectomy was performed. The pathology showed typical 
      PHEO with adrenocortical hyperplasia. VMA, metanefrin and free cortisol levels 
      were normalized one month after surgery. CONCLUSION: The present report is a rare 
      case of PHEO combined with PCS in the same adrenal gland.
FAU - Yaylali, Guzin Fidan
AU  - Yaylali GF
AD  - Pamukkale University, School of Medicine, Department of Endocrinology and 
      Metabolic Diseases, Denizli, Turkey. guzinf@gmail.com
FAU - Akin, Fulya
AU  - Akin F
FAU - Bastemir, Mehmet
AU  - Bastemir M
FAU - Yaylali, Yalin Tolga
AU  - Yaylali YT
FAU - Ozden, Akin
AU  - Ozden A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Canada
TA  - Clin Invest Med
JT  - Clinical and investigative medicine. Medecine clinique et experimentale
JID - 7804071
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adenoma/*complications
MH  - Adrenal Gland Neoplasms/*complications/diagnostic imaging
MH  - Cushing Syndrome/*complications
MH  - Dexamethasone
MH  - Diabetes Mellitus, Type 2/complications
MH  - Humans
MH  - Hydrocortisone/antagonists & inhibitors/blood
MH  - Hyperlipidemias/complications
MH  - Male
MH  - Middle Aged
MH  - Pheochromocytoma/*complications
MH  - Pituitary Neoplasms/*complications
MH  - Ultrasonography
EDAT- 2008/06/12 09:00
MHDA- 2008/08/07 09:00
CRDT- 2008/06/12 09:00
PHST- 2008/06/12 09:00 [pubmed]
PHST- 2008/08/07 09:00 [medline]
PHST- 2008/06/12 09:00 [entrez]
AID - 10.25011/cim.v31i3.3475 [doi]
PST - ppublish
SO  - Clin Invest Med. 2008;31(3):E176-81. doi: 10.25011/cim.v31i3.3475.