PMID- 18546200
OWN - NLM
STAT- MEDLINE
DCOM- 20090512
LR  - 20200930
IS  - 1552-4981 (Electronic)
IS  - 1552-4973 (Linking)
VI  - 88
IP  - 1
DP  - 2009 Jan
TI  - Evaluation of substrates for 90 degrees peel adhesion--a collaborative study. II. 
      Transdermal drug delivery systems.
PG  - 61-5
LID - 10.1002/jbm.b.31149 [doi]
AB  - In a previous study on peel adhesion for medical tapes, it was shown that a 
      stainless steel (SS) substrate better discriminated among medical tapes than a 
      high-density polyethylene (HDPE) substrate. The objective of this study was to 
      determine if a SS substrate would also better distinguish among transdermal drug 
      delivery systems (TDDSs). Five TDDSs (Vivelle Dot, Climara, Catapres-TTS, 
      Duragesic, and Mylan Fentanyl) were evaluated on three different substrates (SS, 
      HDPE, and human cadaver skin). All measurements were made using a dwell time of 
      approximately 3 min, a peel angle of 90 degrees, and a peel speed of 300 mm/min. 
      Differences among TDDSs were greater for SS than for HDPE, using the F statistic 
      for testing for differences among TDDSs means as a measure of heterogeneity, 
      thereby indicating greater discrimination by SS.
CI  - (c) 2008 Wiley Periodicals, Inc.
FAU - Wokovich, Anna M
AU  - Wokovich AM
AD  - Center for Drug Evaluation and Research, Food and Drug Administration, St. Louis, 
      Missouri, USA. anna.wokovich@fda.hhs.gov
FAU - Brown, Stanley A
AU  - Brown SA
FAU - Shen, Meiyu
AU  - Shen M
FAU - Doub, William H
AU  - Doub WH
FAU - Cai, Bing
AU  - Cai B
FAU - Sadrieh, Nakissa
AU  - Sadrieh N
FAU - Chen, Mei Ling
AU  - Chen ML
FAU - Machado, Stella
AU  - Machado S
FAU - Buhse, Lucinda F
AU  - Buhse LF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Biomed Mater Res B Appl Biomater
JT  - Journal of biomedical materials research. Part B, Applied biomaterials
JID - 101234238
RN  - 0 (Biocompatible Materials)
RN  - 4TI98Z838E (Estradiol)
RN  - 9002-88-4 (Polyethylene)
RN  - MN3L5RMN02 (Clonidine)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Adhesiveness
MH  - *Administration, Cutaneous
MH  - Biocompatible Materials/*chemistry
MH  - Cadaver
MH  - Cell Adhesion
MH  - Clonidine/administration & dosage
MH  - *Drug Delivery Systems
MH  - Estradiol/administration & dosage
MH  - Fentanyl/administration & dosage
MH  - Humans
MH  - Materials Testing/*methods
MH  - Polyethylene/chemistry
MH  - Quality Control
MH  - Skin/*drug effects
MH  - *Surgical Tape
EDAT- 2008/06/12 09:00
MHDA- 2009/05/13 09:00
CRDT- 2008/06/12 09:00
PHST- 2008/06/12 09:00 [pubmed]
PHST- 2009/05/13 09:00 [medline]
PHST- 2008/06/12 09:00 [entrez]
AID - 10.1002/jbm.b.31149 [doi]
PST - ppublish
SO  - J Biomed Mater Res B Appl Biomater. 2009 Jan;88(1):61-5. doi: 
      10.1002/jbm.b.31149.