PMID- 18547235
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20221207
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 9
IP  - 3 Pt 1
DP  - 2008 Jun
TI  - Basal insulin and total daily insulin dose in children with type 1 diabetes using 
      insulin pumps.
PG  - 208-13
LID - 10.1111/j.1399-5448.2008.00375.x [doi]
AB  - OBJECTIVE: To assess the contribution of basal insulin to the total daily dose 
      (CBITDD) and to identify the determinant factors in children with type 1 diabetes 
      mellitus. STUDY DESIGN: Cross-sectional study in which the basal insulin 
      requirement was established based on a memory read-out of insulin delivery from 
      pumps. Factors such as glycated haemoglobin A1c (HbA1c), fasting C-peptide, 
      standard deviation score of body mass index (sdsBMI) and demographic data were 
      determined during routine hospital visits. Study group included a total of 90 
      well-controlled diabetic children with the mean HbA1c 6.6 +/- 0.7 (5.2-7.9), age 
      10.4 +/- 4.4 yr (1.1-17.9 yr), diabetes duration 3.0 +/- 2.6 yr (0.3-10.9 yr) and 
      sdsBMI 0.08 (-2.27 to 1.79), excluding patients with ketoacidosis or infectious 
      diseases. RESULTS: Correlations between CBITDD and age (r = 0.39 and p < 0.005) 
      and diabetes duration (r = 0.61 and p < 0.0001) and an inverse correlation with 
      C-peptide (r = -0.41 and p = 0.0001) were found. C-peptide-positive patients had 
      a significantly lower percentage of basal insulin compared with 
      C-peptide-negative patients (20.6 +/- 11 vs. 31.6 +/- 11.0%, respectively; p = 
      0.0004); yet, no significant difference in total insulin daily dose (0.65 +/- 0.3 
      vs. 0.78 +/- 0.2 U/kg/d, respectively) was observed. CONCLUSIONS: The percentage 
      of basal insulin in diabetic children is below 50% and in well-controlled 
      diabetic children is related to the fasting C-peptide level, age of patient and 
      diabetes duration but not to HbA1c and sdsBMI.
FAU - Pankowska, Ewa
AU  - Pankowska E
AD  - The Second Department of Paediatrics, Medical University of Warsaw, Warsaw, 
      Poland. epankowska@interia.pl
FAU - Szypowska, Agnieszka
AU  - Szypowska A
FAU - Lipka, Maria
AU  - Lipka M
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (C-Peptide)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Body Mass Index
MH  - C-Peptide/blood
MH  - Child
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 1/blood/*drug therapy
MH  - Dose-Response Relationship, Drug
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Insulin/*administration & dosage/blood
MH  - *Insulin Infusion Systems
EDAT- 2008/06/13 09:00
MHDA- 2008/08/08 09:00
CRDT- 2008/06/13 09:00
PHST- 2008/06/13 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2008/06/13 09:00 [entrez]
AID - PDI375 [pii]
AID - 10.1111/j.1399-5448.2008.00375.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2008 Jun;9(3 Pt 1):208-13. doi: 
      10.1111/j.1399-5448.2008.00375.x.