PMID- 18547254
OWN - NLM
STAT- MEDLINE
DCOM- 20080820
LR  - 20220321
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 27
IP  - 10
DP  - 2008 May
TI  - Selective visual responses to expansion and rotation in the human MT complex 
      revealed by functional magnetic resonance imaging adaptation.
PG  - 2747-57
LID - 10.1111/j.1460-9568.2008.06249.x [doi]
AB  - Many neurons in the macaque visual area MSTd are sensitive to the global 
      structure of a pattern of moving dots, responding to optic flow components such 
      as expansion and rotation. Direct evidence for neurons with similar properties in 
      humans has been lacking. We have explored sensitivity to optic flow in the human 
      occipital cortex using an event-related functional magnetic resonance imaging 
      adaptation paradigm. On each trial, two brief random-dot kinematograms were 
      presented sequentially. Attention was controlled with a demanding task at 
      fixation. In human MST, the compound response was smaller (indicating adaptation) 
      when the two had the same flow structure than when they were different, 
      suggesting the presence of separate neural populations sensitive to rotation and 
      expansion. Surprisingly, the middle-temporal (MT) gyrus visual area also showed 
      signs of flow specificity, and even V3A showed weak specificity. In V1, which is 
      expected to respond only to local dot motions, no evidence of flow-specific 
      neurons was found. The same was true in V2, V3, V3B and V4. Control experiments 
      showed that the results cannot be attributed to adaptation to local translation 
      within the flow pattern, or to attentional effects. Our results clearly 
      demonstrate selective responses to specific optic flow structures in MST, and we 
      tentatively suggest that the human MT and even V3A may show similar properties.
FAU - Wall, Matthew B
AU  - Wall MB
AD  - Department of Psychology, Royal Holloway, University of London, Egham, Surrey 
      TW20 0EX, UK.
FAU - Lingnau, Angelika
AU  - Lingnau A
FAU - Ashida, Hiroshi
AU  - Ashida H
FAU - Smith, Andrew T
AU  - Smith AT
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Action Potentials/physiology
MH  - Adaptation, Physiological/physiology
MH  - Brain Mapping
MH  - Cerebrovascular Circulation/physiology
MH  - Evoked Potentials, Visual/*physiology
MH  - Humans
MH  - Illusions/physiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Motion Perception/physiology
MH  - Neurons/physiology
MH  - Neuropsychological Tests
MH  - Occipital Lobe/anatomy & histology/*physiology
MH  - Orientation/physiology
MH  - Photic Stimulation
MH  - Rotation
MH  - Space Perception/physiology
MH  - Species Specificity
MH  - Visual Cortex/anatomy & histology/*physiology
MH  - Visual Pathways/anatomy & histology/*physiology
MH  - Visual Perception/*physiology
EDAT- 2008/06/13 09:00
MHDA- 2008/08/21 09:00
CRDT- 2008/06/13 09:00
PHST- 2008/06/13 09:00 [pubmed]
PHST- 2008/08/21 09:00 [medline]
PHST- 2008/06/13 09:00 [entrez]
AID - EJN6249 [pii]
AID - 10.1111/j.1460-9568.2008.06249.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2008 May;27(10):2747-57. doi: 10.1111/j.1460-9568.2008.06249.x.