PMID- 18547320
OWN - NLM
STAT- MEDLINE
DCOM- 20081216
LR  - 20171116
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 142
IP  - 4
DP  - 2008 Aug
TI  - Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in 
      chronic lymphocytic leukaemia identify a disease subset with poor prognosis.
PG  - 529-37
LID - 10.1111/j.1365-2141.2008.07227.x [doi]
AB  - Immunophenotypic studies, fluorescence in situ hybridization (FISH) and 
      conventional karyotyping were used to define the clinicobiological significance 
      of 14q32 translocations involving the immunoglobulin gene locus (14q32/IGH) in 
      252 chronic lymphocytic leukaemia (CLL) patients. The following regions were 
      studied: 13q14, centromere 12, 6q21; 11q22/ATM; 17p13/TP53, 14q32/IGH. Patients 
      were classified as group 1 (favourable, i.e. 13q-single or normal), group 2 
      (intermediate risk, i.e. +12, 6q-, 1-2 anomalies), group 3 (unfavourable, i.e. 
      17p-, 11q-, complex karyotype), or group 4 (14q32/IGH translocation). Endpoints 
      were treatment-free survival (TFS) and overall survival (OS). One hundred and ten 
      patients were included in group 1, 99 in group 2, 25 in group 3 and 18 in group 
      4. 14q32/IGH translocation partners were identified in eight cases (BCL2 in five 
      cases, BCL11A, CCND3 and CDK6 in one case each). group 4 showed shorter TFS 
      versus groups 2 and 1 (25% patients treated at 2 months vs. 12 (P = 0.02) and 20 
      months (P = 0.002), respectively) and shorter OS (25% patients dead at 18 months 
      versus 50 (P = 0.0003) and >60 months (P < 0.0001) respectively. The 14q32/IGH 
      translocation maintained prognostic significance at multivariate analysis on TFS 
      (P = 0.025) and OS (P < 0.001), along with advanced stage and CD38+. These 
      findings show that the 14q32/IGH translocation predicts for an unfavourable 
      outcome in CLL and that this cytogenetic subset might be included as a separate 
      entity in a hierarchical cytogenetic classification of CLL.
FAU - Cavazzini, Francesco
AU  - Cavazzini F
AD  - Section of Haematology, Department of Biomedical Sciences and Advanced Therapies, 
      University of Ferrara, Ferrara, Italy.
FAU - Hernandez, Jose Angel
AU  - Hernandez JA
FAU - Gozzetti, Alessandro
AU  - Gozzetti A
FAU - Russo Rossi, Antonella
AU  - Russo Rossi A
FAU - De Angeli, Cristiano
AU  - De Angeli C
FAU - Tiseo, Ruana
AU  - Tiseo R
FAU - Bardi, Antonella
AU  - Bardi A
FAU - Tammiso, Elisa
AU  - Tammiso E
FAU - Crupi, Rosaria
AU  - Crupi R
FAU - Lenoci, Maria Pia
AU  - Lenoci MP
FAU - Forconi, Francesco
AU  - Forconi F
FAU - Lauria, Francesco
AU  - Lauria F
FAU - Marasca, Roberto
AU  - Marasca R
FAU - Maffei, Rossana
AU  - Maffei R
FAU - Torelli, Giuseppe
AU  - Torelli G
FAU - Gonzalez, Marcos
AU  - Gonzalez M
FAU - Martin-Jimenez, Patricia
AU  - Martin-Jimenez P
FAU - Maria Hernandez, Jesus
AU  - Maria Hernandez J
FAU - Rigolin, Gian Matteo
AU  - Rigolin GM
FAU - Cuneo, Antonio
AU  - Cuneo A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080628
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Immunoglobulin Variable Region)
RN  - EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
SB  - IM
CIN - Br J Haematol. 2009 Jan;144(1):131-3. PMID: 18950454
MH  - ADP-ribosyl Cyclase 1/metabolism
MH  - Aged
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - Female
MH  - Humans
MH  - Immunoglobulin Heavy Chains/*genetics
MH  - Immunoglobulin Variable Region/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics/immunology/mortality
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
MH  - Translocation, Genetic/*genetics
EDAT- 2008/06/13 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/06/13 09:00
PHST- 2008/06/13 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/06/13 09:00 [entrez]
AID - BJH7227 [pii]
AID - 10.1111/j.1365-2141.2008.07227.x [doi]
PST - ppublish
SO  - Br J Haematol. 2008 Aug;142(4):529-37. doi: 10.1111/j.1365-2141.2008.07227.x. 
      Epub 2008 Jun 28.