PMID- 18549677
OWN - NLM
STAT- MEDLINE
DCOM- 20081028
LR  - 20191210
IS  - 0022-3573 (Print)
IS  - 0022-3573 (Linking)
VI  - 60
IP  - 7
DP  - 2008 Jul
TI  - Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 
      cytokine production in-vivo and in-vitro.
PG  - 901-7
LID - 10.1211/jpp.60.7.0012 [doi]
AB  - Schizonepeta tenuifolia (ST) is a major herbal constituent included in treatments 
      for the common cold with fever, ostitis media and other skin inflammations. The 
      present study investigated the effect of ST water extract on the pattern of 
      cytokine production from activated T cells in-vivo and in-vitro. When ST (200 
      mgkg(-1)) was given orally to mice for 7 days before i.v. injection of anti-CD3 
      antibody, it significantly decreased mRNA levels of interleukin (IL)-4, 
      interferon (IFN)-gamma and T-bet. Our flow cytometric analysis showed that ST 
      administration significantly increased CD69 expression but showed little effect 
      on the subsets of T cells. When we cultured mouse CD4 T cells under Th1/Th2 
      differentiation in the presence of ST, the suppressive activity of ST on 
      IFN-gamma involved T-bet, but the downregulation of IL-4 occurred independently 
      of the Th2 transcription factors GATA binding protein 3 (GATA-3) and c-Maf. 
      However, it increased IL-2 secretion during Th1/Th2 differentiation. Our study 
      demonstrates that ST regulates inflammatory responses by reducing the release of 
      Th1 and Th2 cytokines from T cells and prevents unprimed CD4 T cells from 
      differentiating into Th1 and Th2 cells.
FAU - Kang, Hee
AU  - Kang H
AD  - Department of Pathology, College of Oriental Medicine, KyungHee University, 
      Seoul, 130-710, South Korea. shehee@khu.ac.kr
FAU - Oh, Yoo-Joung
AU  - Oh YJ
FAU - Choi, Ho-Young
AU  - Choi HY
FAU - Ham, In-Hye
AU  - Ham IH
FAU - Bae, Hyun-Su
AU  - Bae HS
FAU - Kim, Sung-Hoon
AU  - Kim SH
FAU - Ahn, Kyoo-Seok
AU  - Ahn KS
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Pharm Pharmacol
JT  - The Journal of pharmacy and pharmacology
JID - 0376363
RN  - 0 (CD3 Complex)
RN  - 0 (Cyclohexane Monoterpenes)
RN  - 0 (Immunologic Factors)
RN  - 0 (Monoterpenes)
RN  - 0 (Plant Extracts)
RN  - 207137-56-2 (Interleukin-4)
RN  - 4LF2673R3G (pulegone)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - CD3 Complex/immunology
MH  - Cell Differentiation/drug effects
MH  - Cyclohexane Monoterpenes
MH  - Female
MH  - Immunologic Factors/*pharmacology
MH  - Interferon-gamma/*biosynthesis
MH  - Interleukin-4/*biosynthesis
MH  - Lamiaceae/*chemistry
MH  - Lymphocyte Activation/drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Monoterpenes/analysis
MH  - Plant Extracts/analysis/*pharmacology
MH  - Th1 Cells/drug effects/immunology
MH  - Th2 Cells/drug effects/immunology
EDAT- 2008/06/14 09:00
MHDA- 2008/10/29 09:00
CRDT- 2008/06/14 09:00
PHST- 2008/06/14 09:00 [pubmed]
PHST- 2008/10/29 09:00 [medline]
PHST- 2008/06/14 09:00 [entrez]
AID - 10.1211/jpp.60.7.0012 [doi]
PST - ppublish
SO  - J Pharm Pharmacol. 2008 Jul;60(7):901-7. doi: 10.1211/jpp.60.7.0012.