PMID- 18550014
OWN - NLM
STAT- MEDLINE
DCOM- 20080916
LR  - 20211203
IS  - 1567-5769 (Print)
IS  - 1567-5769 (Linking)
VI  - 8
IP  - 8
DP  - 2008 Aug
TI  - Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory 
      cytokine production and antigen presentation of dendritic cells by impairing 
      NF-kappaB activation.
PG  - 1103-11
LID - 10.1016/j.intimp.2008.04.001 [doi]
AB  - Dendritic cells (DCs) play crucial roles in linking innate immunity and adaptive 
      immunity, thus being regarded as one of the important targets of 
      immunosuppressant. Natural small molecule products isolated from plants, such as 
      fungal metabolites, have been shown to be effective in the treatment of cancer, 
      inflammation and autoimmune diseases. Albaconol is a new kind of prenylated 
      resorcinols isolated from the fruiting bodies of the inedible mushroom 
      Albatrellus confluens, and has been shown to inhibit tumor cell growth. 
      Considering that most of small molecule compounds with antitumor activity always 
      exert immunosuppressive effect, so we wonder whether albaconol could inhibit 
      maturation and antigen presentation of DCs, thus acting as immunosuppressant. 
      Here we demonstrate that albaconol significantly inhibits LPS-induced production 
      of proinflammatory cytokines TNF-alpha, IL-6, IL-1beta, and expression of MHC-II 
      and co-stimulatory molecules by DCs. Furthermore, albaconol markedly inhibits T 
      cell-stimulating capacity of DCs and DCs-initiated antigen-specific T cell 
      response, indicating albaconol can inhibit phenotypic and functional maturation 
      of DCs. Inhibition of LPS-induced NF-kappaB activation may contribute to the 
      above immunosuppressive or anti-inflammatory activities of albaconol. Therefore, 
      our results suggest that natural small molecule albaconol may be a potential 
      immunosuppressive and anti-inflammatory agent through suppressing DCs function 
      via impairment of NF-kappaB activation.
FAU - Liu, Qiuyan
AU  - Liu Q
AD  - Institute of Immunology and National Key Laboratory of Medical Immunology, Second 
      Military Medical University, Shanghai 200433, PR China.
FAU - Shu, Xiaoli
AU  - Shu X
FAU - Sun, Anna
AU  - Sun A
FAU - Sun, Qiaoling
AU  - Sun Q
FAU - Zhang, Chaoxiong
AU  - Zhang C
FAU - An, Huazhang
AU  - An H
FAU - Liu, Jikai
AU  - Liu J
FAU - Cao, Xuetao
AU  - Cao X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080430
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Bridged Bicyclo Compounds)
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (Phenols)
RN  - 0 (albaconol)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*drug effects
MH  - Bridged Bicyclo Compounds/*pharmacology
MH  - CD4-Positive T-Lymphocytes/*drug effects/immunology/metabolism
MH  - Cytokines/immunology/*metabolism
MH  - Dendritic Cells/*drug effects/immunology/metabolism
MH  - Immunosuppression Therapy
MH  - Lipopolysaccharides/immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - NF-kappa B/*metabolism
MH  - Ovalbumin/immunology
MH  - Phagocytosis/drug effects
MH  - Phenols/*pharmacology
EDAT- 2008/06/14 09:00
MHDA- 2008/09/17 09:00
CRDT- 2008/06/14 09:00
PHST- 2008/03/09 00:00 [received]
PHST- 2008/04/01 00:00 [revised]
PHST- 2008/04/02 00:00 [accepted]
PHST- 2008/06/14 09:00 [pubmed]
PHST- 2008/09/17 09:00 [medline]
PHST- 2008/06/14 09:00 [entrez]
AID - S1567-5769(08)00113-6 [pii]
AID - 10.1016/j.intimp.2008.04.001 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2008 Aug;8(8):1103-11. doi: 10.1016/j.intimp.2008.04.001. 
      Epub 2008 Apr 30.