PMID- 18550187
OWN - NLM
STAT- MEDLINE
DCOM- 20081126
LR  - 20080623
IS  - 0168-0102 (Print)
IS  - 0168-0102 (Linking)
VI  - 61
IP  - 4
DP  - 2008 Aug
TI  - Activity-dependent expression of brain-derived neurotrophic factor in dendrites: 
      facts and open questions.
PG  - 335-46
LID - 10.1016/j.neures.2008.04.013 [doi]
AB  - Long-lasting synaptic changes in transmission and morphology at the basis of 
      memory storage, require delivery of newly synthesized proteins to affected 
      synapses. Although many of these proteins are generated in the cell body, several 
      key molecules for plasticity can be delivered in the form of silent mRNAs at 
      synapses in extra somatic compartments where they are locally translated. One of 
      such mRNAs encodes brain-derived neurotrophic factor (BDNF), a key molecule in 
      neuronal development, learning and memory. A single BDNF protein is produced from 
      several splice variants having a different 5' untranslated region. These mRNA 
      variants have a different subcellular localization (soma, proximal or distal 
      dendritic compartment) and may represent a spatial code for a local control of 
      BDNF availability. This review will highlight current knowledge on the mechanisms 
      of spatial and temporal regulation of activity-dependent BDNF mRNA localization 
      in dendrites in relation with synaptic plasticity.
FAU - Tongiorgi, Enrico
AU  - Tongiorgi E
AD  - BRAIN Centre for Neuroscience, Department of Biology, University of Trieste, Via 
      Giorgieri 10, 34127 Trieste, Italy. tongi@units.it
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080504
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Dendrites/*metabolism
MH  - Gene Expression/*physiology
MH  - Models, Biological
MH  - RNA, Messenger/metabolism
RF  - 109
EDAT- 2008/06/14 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/06/14 09:00
PHST- 2008/01/09 00:00 [received]
PHST- 2008/04/18 00:00 [revised]
PHST- 2008/04/22 00:00 [accepted]
PHST- 2008/06/14 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/06/14 09:00 [entrez]
AID - S0168-0102(08)00124-7 [pii]
AID - 10.1016/j.neures.2008.04.013 [doi]
PST - ppublish
SO  - Neurosci Res. 2008 Aug;61(4):335-46. doi: 10.1016/j.neures.2008.04.013. Epub 2008 
      May 4.